D. Natale

Publications83
h-index33
Citations33,031
Highly Influential Citations2,284
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UniProt: the Universal Protein knowledgebase
TLDR
To provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt) consortium. Expand
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The COG database: an updated version includes eukaryotes
TLDR
We describe here a major update of the previously developed system for delineation of Clusters of Orthologous Groups of proteins (COGs) from the sequenced genomes of prokaryotic and unicellular eukaryotes and the construction of clusters of predicted orthologs for 7 eukARYotic genomes, which we named KOGs after euk aryotic o rthologous g roups. Expand
  • 3,708
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The COG database: a tool for genome-scale analysis of protein functions and evolution
TLDR
The database of Clusters of Orthologous Groups of proteins is an attempt on a phylogenetic classification of the proteins encoded in 21 complete genomes of bacteria, archaea and eukaryotes. Expand
  • 2,808
  • 289
The Universal Protein Resource (UniProt)
TLDR
The Universal Protein Resource (UniProt) provides the scientific community with a single, centralized, authoritative resource for protein sequences and functional information. Expand
  • 3,411
  • 221
  • PDF
InterPro: the integrative protein signature database
TLDR
The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or ‘signatures’ representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, SMART, SUPERFAMILY and TIGRFAMs. Expand
  • 1,569
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The COG database: new developments in phylogenetic classification of proteins from complete genomes
TLDR
The database of Clusters of Orthologous Groups of proteins (COGs), which represents an attempt on a phylogenetic classification of the proteins encoded in complete genomes, currently consists of 2791 COGs including 45 350 proteins from 30 genomes of bacteria, archaea and the yeast Saccharomyces cerevisiae. Expand
  • 1,729
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The Universal Protein Resource (UniProt): an expanding universe of protein information
TLDR
The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. Expand
  • 1,037
  • 111
  • PDF
InterPro in 2011: new developments in the family and domain prediction database
TLDR
InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites and makes it freely available to the public via Web-based interfaces and services. Expand
  • 1,049
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The InterPro protein families database: the classification resource after 15 years
TLDR
The InterPro database (http://www.ebi.ac.uk/interpro/) is a freely available resource that can be used to classify sequences into protein families and to predict the presence of important domains and sites. Expand
  • 1,055
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The Universal Protein Resource (UniProt)
TLDR
The ability to store and interconnect all available information on proteins is crucial to modern biological research. Expand
  • 544
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  • PDF