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Nogalamycin

Known as: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-, Nogalamycin [Chemical/Ingredient], 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2a 
An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with… 
National Institutes of Health

Related topics

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13 relations

Broader (4)

Anthracycline AntibioticsAntibiotics, AntineoplasticIntercalating AgentsNucleic Acid Synthesis Inhibitors
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Narrower (1)

disnogalamycin

Papers overview

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1986
1986
Footprinting reveals that nogalamycin and actinomycin shuffle between DNA binding sites.
The hypothesis that sequence-selective DNA-binding antibiotics locate their preferred binding sites by a process involving… 
1981
1981
Template specificity of DNA binding by nogalamycin and its analogs utilizing competitive fluorescence polarization.
Nogalamycin, an anthracycline antibiotic, interacts with DNA. This interaction is measured by a competitive fluorescence… 
1981
1981
Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture.
Nogalamycin is an anthracycline antibiotic which was markedly cytotoxic in vitro and was active against several tumor systems in… 
1980
1980
Simplified toxicologic monitoring of adriamycin, its major metabolites and nogalamycin by reverse-phase high pressure liquid chromatography, Part I: Analytical techniques for isolated human plasma.
A simplified method is presented for routine toxicologic analysis of the antineoplastic drug, adriamycin, and its major… 
Highly Cited
1979
Highly Cited
1979
Comparative biological and biochemical effects of nogalamycin and its analogs on L1210 leukemia.
Abstract Nogalamycin, an anthracycline antibiotic, was active against L1210 leukemia in vitro and in vivo . Several new analogs… 
1979
1979
Treatment of mouse tumors with 7-con-O-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin.
: The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210… 
1979
1979
Treatment of mouse tumors with 7-con-O-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin.
The chemotherapeutic activity of analogs of the anthracycline antibiotic, nogalamycin, was investigated in the P388 and L1210… 
1977
1977
Nogalamycin analogs having improved antitumor activity.
1977
1977
DNA receptor sites for the intercalation of nogalamycin.
The intercalation of the planar chromophoric moiety of nogalamycin between two base pairs of duplex DNA has been evidenced by… 
1976
1976
Reductive microbial conversion of anthracycline antibiotics.
Reductive conversion of several anthracycline glycosides to their 7-deoxyaglycones occurs during their microaerophilic incubation…