Nogalamycin

Known as: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-, Nogalamycin [Chemical/Ingredient], 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2a 
An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with… (More)
National Institutes of Health

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Topic mentions per year

1965-2017
0519652017

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2007
2007
A variety of molecules bind to DNA in its major and minor grooves, and some, like the anthraquinoids, are known to form… (More)
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2001
2001
Fragments spanning 20 kb of Streptomyces nogalater genomic DNA were characterized to elucidate the molecular genetic basis of the… (More)
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1999
1999
The noncovalent binding of the antitumour drugs daunomycin and nogalamycin to duplex DNA has been studied using electrospray… (More)
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1997
1997
The sno gene cluster in Streptomyces nogalater ATCC 27451 contains the nogalamycin biosynthesis genes. A set of plasmid… (More)
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1996
1996
A cluster of anthracycline biosynthetic genes isolated from Streptomyces nogalater was expressed in Streptomyces lividans and in… (More)
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1995
1995
The structure of the self-complementary deoxyoligonucleotide d5'(TGATCA) complexed with nogalamycin, an antitumor anthracycline… (More)
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1991
1991
The anthracycline antibiotic nogalamycin differs from the more common daunomycin-type anthracyclines by substitution on both ends… (More)
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1985
1985
Stopped-flow spectrometry and simple mixing techniques have been employed to investigate the detergent-induced dissociation of… (More)
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1980
1980
The drugs studied included nogalamycin and its derivative 7-con-O-methylnogalarol, dis-nogamycin and its derivative 7-con-O… (More)
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1979
1979
Nogalamycin, an anthracycline antibiotic, was active against Li 210 leukemia in vitro and in vivo. Several new analogs… (More)
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