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Nogalamycin

Known as: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-, Nogalamycin [Chemical/Ingredient], 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2a 
An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with… Expand
National Institutes of Health

Papers overview

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2016
2016
Significance Anthracyclines are complex natural products widely used as anticancer agents. Studies into the biosynthesis of these… Expand
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2012
2012
Nogalamycin is an anthracycline antibiotic that has been shown to exhibit significant cytotoxicity. Its biological activity… Expand
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2008
2008
The structural changes of DNA, induced by the antitumour antibiotic nogalamycin, have been studied by atomic force microscopy… Expand
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2007
2007
  • Vernon G. S. Box
  • Journal of molecular graphics & modelling
  • 2007
  • Corpus ID: 39312841
A variety of molecules bind to DNA in its major and minor grooves, and some, like the anthraquinoids, are known to form… Expand
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Highly Cited
2005
Highly Cited
2005
Interfacial interactions between immobilized DNA probes and DNA-specific sequence binding drugs were investigated using impedance… Expand
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2001
2001
Abstract. Fragments spanning 20 kb of Streptomyces nogalater genomic DNA were characterized to elucidate the molecular genetic… Expand
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1999
1999
The noncovalent binding of the antitumour drugs daunomycin and nogalamycin to duplex DNA has been studied using electrospray… Expand
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1979
1979
Abstract Nogalamycin, an anthracycline antibiotic, was active against L1210 leukemia in vitro and in vivo . Several new analogs… Expand
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Highly Cited
1978
Highly Cited
1978
Abstract The highly active, quinone-containing anticancer drugs, Adriamycin, daunorubicin, carminomycin, rubidazone, nogalamycin… Expand
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Highly Cited
1965
Highly Cited
1965
Echinomycin, daunomycin, ethidium bromide, nogalamycin, chromomycin, mithramycin, and olivomycin inhibit RNA synthesis by RNA… Expand
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