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Nogalamycin

Known as: 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha))-, Nogalamycin [Chemical/Ingredient], 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-14-carboxylic acid, 11-((6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R-(2a 
An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater. Nogalamycin intercalates into DNA and interacts with… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (4)

Anthracycline AntibioticsAntibiotics, AntineoplasticIntercalating AgentsNucleic Acid Synthesis Inhibitors
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Narrower (1)

disnogalamycin

Papers overview

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2001
2001
Expeditious synthesis of C-glycosyl conjugated dienes and aldehydes from sugar lactones
Highly Cited
1991
Highly Cited
1991
DNA-nogalamycin interactions.
The anthracycline antibiotic nogalamycin differs from the more common daunomycin-type anthracyclines by substitution on both ends… 
1990
1990
Solution structure of the nogalamycin-DNA complex.
The nogalamycin-d(A-G-C-A-T-G-C-T) complex (two drugs per duplex) has been generated in aqueous solution and its structure… 
Highly Cited
1989
Highly Cited
1989
Antitumor drug nogalamycin binds DNA in both grooves simultaneously: molecular structure of nogalamycin-DNA complex.
The three-dimensional molecular structures of the complexes between an interesting antitumor drug, nogalamycin, and two DNA… 
Highly Cited
1988
Highly Cited
1988
NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5'-GCATGC)2.
1H resonance assignments in the NMR spectra of the self-complementary hexadeoxyribonucleoside pentaphosphate d(5'-GCATGC)2 and… 
Highly Cited
1979
Highly Cited
1979
Comparative biological and biochemical effects of nogalamycin and its analogs on L1210 leukemia.
Abstract Nogalamycin, an anthracycline antibiotic, was active against L1210 leukemia in vitro and in vivo . Several new analogs… 
Highly Cited
1968
Highly Cited
1968
Initiation of chains by RNA polymerase and the effects of inhibitors studied by a direct filtration technique.
1968
1968
The inhibition of rabies virus by arabinosyl cytosine. Studies on the mechanism and specificity of action.
Highly Cited
1966
Highly Cited
1966
Le phénomène de la ségrégation nucléolaire: Spécificité d'action de certains antimétabolites
Sous l'effet de certains composés, le nucléole présente des lésions morphologiques distinctes et caractéristiques. Ces lésions… 
Highly Cited
1966
Highly Cited
1966
Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin…
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