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The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing
TLDR
In vivo and in vitro analyses demonstrate that the Mtr4 arch domain is required for proper 5.8S rRNA processing, and suggest that the arch functions independently of canonical helicase activity.
The Fas/FADD death domain complex structure unravels signaling by receptor clustering
TLDR
The result is a regulatory Fas–FADD complex bridge governed by weak protein–protein interactions revealing a model where the complex itself functions as a mechanistic switch that prevents accidental DISC assembly, yet allows for highly processive DISC formation and clustering upon a sufficient stimulus.
Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif*
TLDR
It is found that UIM peptides from several proteins involved in endocytosis and vacuolar protein sorting including Hrs, Vps27p, Stam1, and Eps15 bound specifically, but with modest affinity, to free ubiquitin.
Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa*
TLDR
It is demonstrated that PelD binds c-di-GMP with low micromolar affinity and that mutation of residues involved in binding not only decreases the affinity of this interaction but also abrogates PEL-specific phenotypes in vivo.
Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex*
TLDR
This work solved the x-ray crystal structure of Hha in complex with the N-terminal dimerization domain of H-NS to 3.2 Å resolution and shows for the first time how Hha and H- NS interact to direct transcriptional repression and reveals that a positively charged surface of H Ha enhances the silencing activity of H.NS nucleoprotein filaments.
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