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Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.
The pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral glycoprotein. Two virus-neutralizing monoclonal antibodies have beenExpand
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Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.
Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabiesExpand
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Antigenic diversity of the glycoprotein and nucleocapsid proteins of rabies and rabies-related viruses: implications for epidemiology and control of rabies.
Rabies virus-specific monoclonal antibodies (MAbs) have served to describe operationally the topography of the antigenic structure of the glycoprotein and nucleocapsid proteins of rabies virus. WithExpand
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Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene.
Inoculation of rabbits and mice with a vaccinia-rabies glycoprotein recombinant (V-RG) virus resulted in rapid induction of high concentrations of rabies virus-neutralizing antibodies and protectionExpand
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Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.
More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, orExpand
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Antigenic sites on the CVS rabies virus glycoprotein: analysis with monoclonal antibodies.
Antigenic variation in the glycoprotein of rabies (CVS-11) virus was studied. Neutralization-resistant variant viruses were isolated in vitro at high frequency (10(-4) to 10(-5)) in the presence ofExpand
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Antigenic analysis of rabies and Mokola virus from Zimbabwe using monoclonal antibodies.
Eighteen strains of virus were recovered by tissue culture techniques from 20 samples of mouse brain received from Harare, Zimbabwe, and typed with monoclonal antibodies at The Wistar Institute. OnExpand
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Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants.
Somatic cell hybrids (hybridomas) between mouse myeloma cells and spleen cells derived from BALB/c mice immunized with inactivated rabies vaccine were found to produce antibodies to rabies virus.Expand
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Antigenic properties of rabies virus components.
The envelope glycoprotein of rabies virus was shown to be the antigen responsible for the induction of virus neutralizing (VN) antibody formation and for the protection of animals against subsequentExpand
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Finally, because of good antigenic properties demonstrated either by the live attenuated HEP virus or by inactivated CVS and PM viruses grown in WI-38, an ideal medium for the production of humanExpand
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