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NSC 366140

Known as: NSC-366140 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

AcridinesAntineoplastic AgentsIntercalating AgentsPyrazoles
PD 115934

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Antitumor Efficacy of PD 115934 ( NSC 366140 ) against Solid Tumors of Mice 1
PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the… 
2004
2004
The Metabolism of Pyrazoloacridine (NSC 366140) by Cytochromes P450 and Flavin Monooxygenase in Human Liver Microsomes
Pyrazoloacridine (PZA) is an experimental antitumor agent presently under investigation for treatment of solid tumors on the… 
2004
2004
Synergistic Cytotoxicity of Pyrazoloacridine with Doxorubicin, Etoposide, and Topotecan in Drug-Resistant Tumor Cells
Pyrazoloacridine (NSC 366140, PD115934, PZA) is a new class of acridine anticancer agents under investigation in Phase II… 
2002
2002
A Phase I and Pharmacologic Study of Pyrazoloacridine (NSC 366140) and Carboplatin in Patients with Advanced Cancer
AbstractBackground: Pyrazoloacridine (PZA) is thefirst of a new class of rationallysynthesized acridine derivatives to… 
Highly Cited
1998
Highly Cited
1998
Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II.
Pyrazoloacridine (PA), an acridine congener with an unknown mechanism of action, has shown selective activity against solid tumor… 
1996
1996
Identification and antitumor activity of a reduction product in the murine metabolism of pyrazoloacridine (NSC-366140)
Purpose. Pyrazoloacridine (PZA) is a newly developed anticancer agent currently undergoing clinical trials. Its mode of action… 
1995
1995
Pharmacokinetics of 9-methoxy-N,N-dimethyl-5-nitropyrazolo [3,4, 5-kl]acridine-2(6H)-propanamine (PZA, PD 115934, NSC 366140) in mice: guidelines for early clinical trials1.
Pharmacokinetic studies that consisted of measuring the plasma drug profile, tissue drug distribution, and elimination in urine… 
Highly Cited
1990
Highly Cited
1990
Antitumor efficacy of PD115934 (NSC 366140) against solid tumors of mice.
PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the… 
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