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Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential.
Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa.
- M. Winson, M. Cámara, B. Bycroft
- BiologyProceedings of the National Academy of Sciences…
- 26 September 1995
Using HPLC, mass spectrometry, and NMR spectroscopy, it is established that in Escherichia coli, VsmI directs the synthesis of N-butanoyl-L-homoserine lactone (BHL) and N-hexanoyL- L-homologically-based lactones (HHL).
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.
Data show that rictor regulates the ability of ILK to promote Akt phosphorylation and cancer cell survival, as well as identifying integrin-linked kinase (ILK) interactors.
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including tumours resistant to PARP inhibition.
Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects.
- A. M. Ponce, B. Viglianti, M. Dewhirst
- Biology, MedicineJournal of the National Cancer Institute
- 3 January 2007
A novel magnetic resonance imaging method was used to measure the temporal and spatial patterns of drug delivery in a rat fibrosarcoma model during treatment with LTSLs containing doxorubicin and an MRI contrast agent, which yielded a peripheral drug distribution.
Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models.
- M. Webb, T. Harasym, D. Masin, M. Bally, L. Mayer
- Biology, MedicineBritish Journal of Cancer
- 1 October 1995
The developed liposomal formulation of vincristine with significantly enhanced stability and biological properties based on sphingomyelin and cholesterol had significantly greater in vitro stability than did similar DSPC/cholesterol liposomes.
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
The findings show that CAIX is vital for growth and metastasis of hypoxic breast tumors and is a specific, targetable biomarker for breast cancer metastasis.
Generation of multilamellar and unilamellar phospholipid vesicles
Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
Fixing synergistic drug ratios in pharmaceutical carriers provides an avenue by which anticancer drug combinations can be optimized prospectively for maximum therapeutic activity during preclinical development and differs from current practice in which dosing regimens are developed empirically in late-stage clinical trials based on tolerability.
Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol)
All aspects of PEG are examined in order to gain a better understanding of how the polymer fulfills its biological role and the physical and chemical properties of the polymer are explored and compared to properties of other hydrophilic polymers.