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Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
TLDR
Selenium or vitamin E, alone or in combination at the doses and formulations used, did not prevent prostate cancer in this population of relatively healthy men.
Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine
TLDR
This trial confirms the effectiveness of imatinib as primary systemic therapy for patients with incurable GIST but did not show any advantage to higher dose treatment.
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study
TLDR
Although somewhat more neutropenia, elevations in AST/ALT, emesis, and fatigue occurred in the q3 weeks 24-hour trabectedin regimen, this regimen was reasonably well tolerated and may now be considered an important new option to control advanced sarcomas in patients after failure of available standard-of-care therapies.
Cutaneous angiosarcoma of the scalp
Angiosarcoma is a malignant tumor of vascular endothelial cells that arises in the head and neck. It is a rare, difficult to treat, and lethal tumor.
Integrative Clinical Genomics of Metastatic Cancer
TLDR
The results show that integrative sequence analysis provides a clinically relevant, multi-dimensional view of the complex molecular landscape and microenvironment of metastatic cancers.
Chordoma: the nonsarcoma primary bone tumor.
TLDR
Patients who relapse locally have a poor prognosis but both radiation and surgery can be used as salvage therapy, and subtotal resection can result in a stable or improved status in as many as 50% of patients who relapse after primary therapy.
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
TLDR
Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men in relatively healthy men.
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