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Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
TLDR
Four colon tumors survived the first transplant and are now in serial passage, and two tumors are highly metastatic, and at least one of these is known to be suitable for surgery-chemotherapy adjuvant studies.
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Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice.
TLDR
High cure rates were obtained with Adriamycin treatment, and limited therapeutic responses were seen to treatment with cis-diamminedichloroplatinum or cyclophosphamide.
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Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from…
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Magnetic Resonance Imaging Measurements of the Response of Murine and Human Tumors to the Vascular-Targeting Agent ZD6126
TLDR
The contrast enhanced-MRI measured median IAUC is a useful end point for quantifying ZD6126 antivascular effects in human tumors and shows a significant trend of increasing reductions with increasing exposure.
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In Vivo Methods for Screening and Preclinical Testing
The classic question in the field of drug discovery is: Which tumor model is a satis-factory predictor for cancer in humans? The classic answer is: None of them!
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In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
TLDR
Levels of free TS in the tumor after 5-FUra treatment are predictive of chemotherapeutic response in these murine models of human colonic adenocarcinoma, and could not be explained by the small differences among the tumors in total perchloric acid-soluble metabolites of 5-UFra or drug incorporation into RNA.
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Establishment of cross-resistance profiles for new agents.
TLDR
The cross-resistance profiles of drug-resistant murine tumors to treatment with new drugs going into phase I-II trials should provide useful guides for patient selection for those trials, as well as indicating likely biochemical mechanism of action of new drugs with promising anticancer activity.
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Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.
TLDR
Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.
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Formulation and Antitumor Activity Evaluation of Nanocrystalline Suspensions of Poorly Soluble Anticancer Drugs
TLDR
Wet milling technology is a feasible approach for formulating poorly water soluble chemotherapeutic agents that may offer a number of advantages over a more classical approach and shows the feasibility of formulating well water soluble anticancer agents as physically stable aqueous nanocrystalline suspensions.
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Toxicity and anticancer activity of a new triazine antifolate (NSC 127755).
TLDR
A new triazine folate antagonist was highly active against four transplantable colon adenocarcinomas and the Dunning murine ovarian tumor M5076 and treatment schedule studies indicated that a prolonged time of exposure provided optimum antitumor activity for the compound.
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