NLRP3 gene

Known as: AII, PYPAF1, NLR family, pyrin domain containing 3 
This gene plays a role in both inflammation and apoptosis.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Inflammasomes are multiprotein complexes that critically control different aspects of innate and adaptive immunity. Among them we… (More)
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Highly Cited
2015
Highly Cited
2015
The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome is a component of the inflammatory… (More)
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Highly Cited
2012
Highly Cited
2012
Alzheimer’s disease is the world’s most common dementing illness. Deposition of amyloid-β peptide drives cerebral… (More)
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Highly Cited
2012
Highly Cited
2012
We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling… (More)
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Highly Cited
2011
Highly Cited
2011
An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host ‘danger’, including… (More)
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Highly Cited
2011
Highly Cited
2011
The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Chronic inflammation of the arterial wall is a key element in the pathogenesis of atherosclerosis, yet the factors… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18 are central players in the pathogenesis of… (More)
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Highly Cited
2009
Highly Cited
2009
The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine… (More)
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Highly Cited
2009
Highly Cited
2009
Virus-induced interlukin-1beta (IL-1beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple… (More)
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