• Publications
  • Influence
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
BACKGROUND High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages. We hypothesized that the capacity of HDL to acceptExpand
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Use of cyclodextrins for manipulating cellular cholesterol content.
Previous studies from this laboratory have demonstrated that exposure of tissue culture cells to cyclodextrins results in rapid cholesterol depletion. In the present study, we have developedExpand
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Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.
Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro andExpand
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Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport.
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic properties, including the ability to mediate macrophage cholesterol efflux, antioxidant capacity, antiinflammatoryExpand
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The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis This work was supported by P01-HL22633 from the NHLBI. Published, JLR Papers in Press, December 8,
Reverse cholesterol transport (RCT) is a term used to describe the efflux of excess cellular cholesterol from peripheral tissues and its return to the liver for excretion in the bile and ultimatelyExpand
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Overexpression of Apolipoprotein A-I Promotes Reverse Transport of Cholesterol From Macrophages to Feces In Vivo
Background—Abundant data indicate that overexpression of apolipoprotein A-I (apoA-I) in mice inhibits atherosclerosis. One mechanism is believed to be promotion of reverse cholesterol transport, butExpand
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Importance of different pathways of cellular cholesterol efflux.
The removal of excess free cholesterol from cells by HDL or its apolipoproteins is important for maintaining cellular cholesterol homeostasis. This process is most likely compromised in theExpand
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Cellular Cholesterol Efflux Mediated by Cyclodextrins (*)
In this study, we compared cholesterol efflux mediated by either high density lipoproteins (HDL3) or β-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their hydrophobicExpand
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High-density lipoprotein heterogeneity and function in reverse cholesterol transport
Purpose of review HDL is a cardioprotective lipoprotein, at least in part, because of its ability to mediate reverse cholesterol transport (RCT). It is becoming increasingly clear that theExpand
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Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux*
  • Y. Ji, Bao Jian, +6 authors A. Tall
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 22 August 1997
Scavenger receptor BI (SR-BI) binds high density lipoproteins (HDL) with high affinity and mediates the selective uptake of HDL cholesteryl ester. We examined the potential role of SR-BI in mediatingExpand
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