NLRP3 protein, human

Known as: Angiotensin/Vasopressin Receptor AII/AVP-Like, Cryopyrin, PYRIN-containing Apaf1-like protein 1, human 
NACHT, LRR and PYD domains-containing protein 3 (1034 aa, ~118 kDa) is encoded by the human NLRP3 gene. This protein plays a role in the modulation… (More)
National Institutes of Health

Papers overview

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2012
2012
BACKGROUND Cryopyrin-associated periodic syndromes (CAPS) are rare, inherited autoinflammatory disorders associated with… (More)
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Highly Cited
2009
Highly Cited
2009
Virus-induced interlukin-1beta (IL-1beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple… (More)
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Highly Cited
2009
Highly Cited
2009
Bacterial infection elicits a range of beneficial as well as detrimental host inflammatory responses. Key among these responses… (More)
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Review
2009
Review
2009
The innate immune system is critical in recognizing bacterial and viral infections to evoke a proper immune response. Certain… (More)
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2008
2008
Mutations in NLRP3 (CIAS1) are identified in a continuum of related inflammatory disorders, known as cryopyrinopathies since… (More)
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Highly Cited
2006
Highly Cited
2006
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… (More)
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Highly Cited
2006
Highly Cited
2006
Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle… (More)
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Highly Cited
2006
Highly Cited
2006
Mutations in cryopyrin and pyrin proteins are responsible for several autoinflammatory disorders in humans, suggesting that these… (More)
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Review
2005
Review
2005
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Familial cold autoinflammatory syndrome (FCAS) is an autosomal dominant disorder characterised by recurrent episodes… (More)
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