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NLRP3 protein, human

Known as: Angiotensin/Vasopressin Receptor AII/AVP-Like, Cryopyrin, PYRIN-containing Apaf1-like protein 1, human 
NACHT, LRR and PYD domains-containing protein 3 (1034 aa, ~118 kDa) is encoded by the human NLRP3 gene. This protein plays a role in the modulation… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Virus-induced interlukin-1beta (IL-1beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple… Expand
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Highly Cited
2009
Highly Cited
2009
Glyburide, a sulfonylurea drug commonly used to treat type 2 diabetes, shuts down IL-1β secretion by preventing Cyropyrin… Expand
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Review
2009
Review
2009
Summary:  The innate immune system is critical in recognizing bacterial and viral infections to evoke a proper immune response… Expand
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Highly Cited
2007
Highly Cited
2007
Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine… Expand
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Highly Cited
2006
Highly Cited
2006
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of… Expand
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Highly Cited
2006
Highly Cited
2006
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… Expand
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Highly Cited
2006
Highly Cited
2006
Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle… Expand
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Highly Cited
2006
Highly Cited
2006
Viral infection induces the production of interleukin (IL)-1β and IL-18 in macrophages through the activation of caspase-1, but… Expand
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Review
2005
Review
2005
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Familial cold autoinflammatory syndrome (FCAS) is an autosomal dominant disorder characterised by recurrent episodes… Expand
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