Angiotensin II receptors and angiotensin II receptor antagonists.
- P. Timmermans, P. Wong, R. Smith
- BiologyPharmacological Reviews
- 1 June 1993
Identification of angiotensin II receptor subtypes.
- A. Chiu, W. Herblin, A. Johnson
- Biology, ChemistryBiochemical and Biophysical Research…
- 30 November 1989
Angiotensin II receptor subtypes.
- P. Timmermans, A. Chiu, W. Herblin, P. Wong, R. Smith
- BiologyAmerican Journal of Hypertension
- 1 June 1992
The AT1 and AT2 receptor subtypes/binding sites identified so far appears widespread and the presence and proportion of these receptors vary significantly among different tissues/organs of the same species and within the same tissue/organ of different species.
Angiotensin II receptors and functional correlates.
- P. Timmermans, P. Benfield, A. Chiu, W. Herblin, P. Wong, R. Smith
- BiologyAmerican Journal of Hypertension
- 1 December 1992
The angiotensin receptor and its functional correlates have been redefined by the cloning of angiotENSin receptors and the discovery and widespread study of specific nonpeptide ANG II-receptor antagonists losartan (AT1 selective) and PD123177 (AT2 selective).
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
- P. Wong, W. Price, P. Timmermans
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 1990
The results demonstrate that EXP3174 is a selective and noncompetitive AII receptor antagonist and lacks agonistic effect and may be responsible for part of the antihypertensive effect of DuP 753 in rats.
Proposed update of angiotensin receptor nomenclature.
- M. de Gasparo, A. Husain, P. Timmermans
- BiologyHYPERTENSION
- 1 May 1995
Angiotensin II exerts a wide range of actions on the heart, blood vessels, adrenals, kidneys, and nervous system and plays a major role in blood pressure maintenance and volume homeostasis. Its…
Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
- P. Wong, S. Hart, P. Timmermans
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1990
A function of the PD123177-sensitive AII binding site (AII-2) has not yet been identified, however, the DuP 753-sensitive site appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release from sympathetic ganglia, drinking and vasoconstriction.
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.
A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared, and it has been found that the acidic group at the 2'-position of the biphenyl is essential.
Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.
- P. Wong, W. Price, P. Timmermans
- Medicine, BiologyHYPERTENSION
- 1 May 1990
The results suggest that the renin-angiotensin system plays a significant role in the control of blood pressure in spontaneously hypertensive rats, and indicates that captopril would need to be supplemented by a diuretic to reduce blood pressure to a similar extent as that of DuP 753.
Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.
- A. Chiu, W. Roscoe, D. E. McCall, P. Timmermans
- Biology, MedicineReceptor
- 1991
Data indicate that the AII receptors on aortic smooth muscle cells of the rat are of the A II-1 receptor subtype, which is responsible for both the vasoconstrictor and hypertrophic responses of AII.
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