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NBN gene

Known as: AT-V1, NBN, NIBRIN 
This gene plays a role in DNA repair and cell cycle checkpoints.
National Institutes of Health

Related topics

Related topics

11 relations
Acute lymphocytic leukemiaApoptosisCell Cycle CheckpointsDNA Repair

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NBN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The RING Finger Protein RNF8 Ubiquitinates Nbs1 to Promote DNA Double-strand Break Repair by Homologous Recombination*
Background: The Mre11-Rad50-Nbs1 (MRN) complex and the ubiquitin E3 ligase RNF8 play important roles in DNA DSB repair. Results… 
Highly Cited
2009
Highly Cited
2009
Design, Synthesis, and Biological Evaluation of Enantiomeric β‐N‐Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay‐Sachs and Sandhoff Disease
Combating glycolipid storage disorders: LABNAc was prepared in an efficient 11‐step procedure from D‐lyxonolactone. The… 
Highly Cited
2008
Highly Cited
2008
Mdm2 Promotes Genetic Instability and Transformation Independent of p53
ABSTRACT Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has… 
Review
2007
Review
2007
A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
In mammalian cells, DNA is often subjected to stresses such as ionizing radiation (IR) and ultraviolet light that can induce DNA… 
Highly Cited
2006
Highly Cited
2006
E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts
Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and… 
Highly Cited
2005
Highly Cited
2005
Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection*
Eukaryotic cells are equipped with machinery to monitor and repair damaged DNA. Herpes simplex virus (HSV) DNA replication occurs… 
Highly Cited
2004
Highly Cited
2004
ATM is required for the cellular response to thymidine induced replication fork stress.
Genetically distinct checkpoints, activated as a consequence of either DNA replication arrest or ionizing radiation-induced DNA… 
Review
2002
Review
2002
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11
The accumulation of DNA repair proteins at the sites of DNA damage can be visualized in mutagenized cells at the single cell… 
Highly Cited
1999
Highly Cited
1999
Patterned polymer growth on silicon surfaces using microcontact printing and surface-initiated polymerization
Patterned polymer films were grown on SiO2/Si surfaces by a process starting with microcontact printing (μCP) of… 
Review
1999
Review
1999
Radiation, DNA damage and cancer.
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