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Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.
Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms, and only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds. Expand
Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application
Abstract Alkaloids mimicking the structures of monosaccharides are now believed to be widespread in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a structuralExpand
Iminosugars as therapeutic agents: recent advances and promising trends.
The field of iminosugars continues to open up exciting new opportunities for therapeutic agent discovery and offers many new tools for precisely modifying carbohydrate structures and modulating glycosidase activity in vivo. Expand
Ring contraction of 2-O-trifluoromethanesulphonates of α-hydroxy-γ-lactones to oxetane carboxylic esters
Abstract 2-O-Trifluoromethanesulphonate esters of the four diastereomeric 3,5-di-O-benzyl-pentono-1,4-1actones gave, on treatment with potassium carbonate in methanol, efficient ring contraction toExpand
Direct production of L-tagatose from L-psicose by Enterobacter aerogenes 230S.
L-tagatose was produced directly from L-psicose by subjecting the same biomass suspension to microbial reduction followed by oxidation using a newly isolated bacteria Enterobacter aerogenes 230S and it was observed that cells grown on xylitol have the best conversion potential. Expand
Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharides
Abstract ]The inhibitory activities of three plant alkaloids, deoxynojirimycin, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine and 1,5 dideoxy-1,5-imino- D -mannitol towards glycosidases from severalExpand
Polyhydroxylated pyrrolidines from sugar lactomes: Synthesis of 1,4-dideoxy-1,4-imino-d-glucitol from d-galactonolactone and syntheses of 1,4-dideoxy-1,4-imino-d-allitol,
Abstract The use of readily available sugar lactones in the synthesis of polyhydroxylated pyrrolidines is illustrated by the preparation of the glucosidase inhibitor 1,4-dideoxy-1, 4-imino-D-glucitolExpand
Isolation of glycosidase-inhibiting hyacinthacines and related alkaloids from Scilla socialis.
The structures of the new alkaloids were elucidated by spectroscopic methods as beta-1-C-ethyldeoxymannojirimycin, hyacinthacines B7, C2, C3, C4, and C5, and alpha-5-C-(3-hydroxybutyl)hyacinthACine A2, the first report of their occurrence in the plant family Hyacinthaceae. Expand
Australine and related alkaloids: easy structural confirmation by 13C NMR spectral data and biological activities
Abstract The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legumeExpand