C. Smythe

Publications62
h-index25
Citations3,527
Highly Influential Citations146
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INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
Cytoskeletal rearrangements during mitosis must be co-ordinated with chromosome movements. The 'chromosomal passenger' proteins [1], which include the inner centromere protein (INCENP [2]), the… Expand
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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
ATR is a large, >300 kDa protein containing a carboxy-terminus kinase domain related to PI-3 kinase, and is homologous to the ATM gene product in human cells and the rad3/MEC1 proteins in yeast.… Expand
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Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz-Jeghers cancer syndrome. We previously found that LKB1 was… Expand
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Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2
In cell-free extracts derived from Xenopus eggs which oscillate between S phase and mitosis, incompletely replicated DNA blocks the activation of p34cdc2-cyclin by maintaining p34cdc2 in a… Expand
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Incorporation of the nuclear pore basket protein Nup153 into nuclear pore structures is dependent upon lamina assembly: evidence from cell‐free extracts of Xenopus eggs
In cell‐free extracts of Xenopus eggs that support the assembly of replication‐competent nuclei, we found that lamin B3 specifically associates with four polypeptides (termed SLAPs, soluble lamin… Expand
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Activation of mammalian Chk1 during DNA replication arrest
Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an… Expand
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Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28‐Ccn1/Hgc1 kinase
Polarized growth is a fundamental property of cell growth and development. It requires the delivery of post‐Golgi secretory vesicles to the site of polarized growth. This process is mediated by Rab… Expand
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DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
DNA and histone synthesis are coupled and ongoing replication is required to maintain histone gene expression. Here, we expose S phase–arrested cells to the kinase inhibitors caffeine and LY294002.… Expand
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Assembly/disassembly of the nuclear envelope membrane: Cell cycle-dependent binding of nuclear membrane vesicles to chromatin in vitro
Dissociation and association of membranes with chromatin at the beginning and end of mitosis are critical in controlling nuclear dynamics during these stages of the cell cycle. Employing purified… Expand
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Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
BACKGROUND A common event in the development of human neoplasia is the inactivation of a damage-inducible cell-cycle checkpoint pathway regulated by p53. One approach to the restoration of this… Expand
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