NBN wt Allele

Known as: AT-V1 Gene, Nijmegen Breakage Syndrome 1 Gene, P95 
Human NBN wild-type allele is located within 8q21 and is approximately 51 kb in length. This allele, which encodes nibrin protein, is involved in DNA… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence… (More)
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Highly Cited
2007
Highly Cited
2007
MRE11-RAD50-NBS1 (MRN) is a conserved nuclease complex that exhibits properties of a DNA damage sensor and is critical in… (More)
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Highly Cited
2005
Highly Cited
2005
Nijmegen breakage syndrome (NBS) is characterised by microcephaly, developmental delay, characteristic facial features… (More)
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Highly Cited
2004
Highly Cited
2004
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular… (More)
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Highly Cited
2003
Highly Cited
2003
Cell cycle checkpoints are signal transduction pathways activated after DNA damage to protect genomic integrity. Dynamic… (More)
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Highly Cited
2001
Highly Cited
2001
HER2 is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It undergoes… (More)
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Highly Cited
2001
Highly Cited
2001
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive human disease whose clinical features include growth retardation… (More)
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Highly Cited
1999
Highly Cited
1999
BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts… (More)
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Highly Cited
1998
Highly Cited
1998
Genetic studies in yeast have indicated a role of the RAD50 and MRE11 genes in homologous recombination, telomere length… (More)
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Highly Cited
1993
Highly Cited
1993
We have recently characterized a 95 kDa protein, p95, which exhibits enhanced binding to temperature-sensitive p53 (ts-p53) when… (More)
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