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NBN wt Allele

Known as: AT-V1 Gene, Nijmegen Breakage Syndrome 1 Gene, P95 
Human NBN wild-type allele is located within 8q21 and is approximately 51 kb in length. This allele, which encodes nibrin protein, is involved in DNA… 
National Institutes of Health

Related topics

Related topics

14 relations
8q21-q24ATM Signaling PathwayAcute lymphocytic leukemiaApoptosis

Broader (1)

NBN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): a randomised trial
Review
2005
Review
2005
Report on childhood obesity in China (1)--body mass index reference for screening overweight and obesity in Chinese school-age children.
  • C. Ji
  • Biomedical and environmental sciences : BES
  • 2005
  • Corpus ID: 28139615
PURPOSE To establish and propose a national body mass index (BMI) reference for screening overweight and obesity in Chinese… 
Highly Cited
2005
Highly Cited
2005
Nbs1 is required for ATR‐dependent phosphorylation events
Nijmegen breakage syndrome (NBS) is characterised by microcephaly, developmental delay, characteristic facial features… 
Highly Cited
2003
Highly Cited
2003
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
53BP1 and NFBD1/MDC1 are recruited rapidly to sites of DNA double-strand breaks (DSBs), where they are hypothesized to function… 
Highly Cited
2002
Highly Cited
2002
NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain
Highly Cited
2001
Highly Cited
2001
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
Highly Cited
1999
Highly Cited
1999
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts… 
Highly Cited
1998
Highly Cited
1998
The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response
Highly Cited
1998
Highly Cited
1998
NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer.
We identified an NH2-terminally truncated HER-2/neu product of M(r) 95,000 with in vitro kinase activity by Western blotting and… 
Highly Cited
1992
Highly Cited
1992
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
SEVERAL proteins implicated in the regulation of cellular responses to mitogenic stimuli contain a common non-catalytic domain… 
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