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A telomerase component is defective in the human disease dyskeratosis congenita
It is found that primary fibroblasts and lymphoblasts from DKC-affected males are not detectably deficient in conventional H/ACA small nucleolar RNA accumulation or function; however, DKC cells have a lower level of telomerase RNA, produce lower levels of telomersase activity and have shorter telomeres than matched normal cells.
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
- K. Collins, Benjamin K. Chen, S. Kalams, B. Walker, D. Baltimore
- Biology, MedicineNature
- 22 January 1998
It is found that CTLs inefficiently lysed primary cells infected with HIV-1 if the viral nef gene product was expressed and Nef protected infected cells by reducing the epitope density on their surface.
Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct…
A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
It is demonstrated that a heterologous sno RNA can function to promote chimeric RNA accumulation and 3′ end processing but not telomerase activity, and the structural and functional diversity of the box H/ACA snoRNA motif is expanded.
HIV–1 Infects Multipotent Progenitor Cells Causing Cell Death and Establishing Latent Cellular Reservoirs
A unique reporter HIV that directly detects latently infected cells in vitro confirmed the presence of distinct populations of active and latent infected HPCs, which have major implications for understanding HIV bone marrow pathology and the mechanisms by which HIV causes persistent infection.
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase.
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
- J. Roeth, Maya Williams, M. Kasper, Tracey M Filzen, K. Collins
- BiologyThe Journal of cell biology
- 6 December 2004
Evidence suggests that binding of AP-1 to the Nef–MHC-I complex is an important step required for inhibition of antigen presentation by HIV.
Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways
It is suggested that Nef generates pleiotrophic effects in the secretory and endocytic pathways that reprogram intracellular protein trafficking and may ultimately provide an efficient platform for viral assembly.
Starvation-induced Cleavage of the tRNA Anticodon Loop in Tetrahymena thermophila*
It is suggested that anticodon loop cleavage may reduce the accumulation of uncharged tRNAs as part of a specific response induced by amino acid starvation.
Telomerase: an RNP enzyme synthesizes DNA.
The underlying conservation of a core set of structural features of telomerase RNAs important for the fundamental polymerase activity of telomersase are described, which include a pseudoknot-plus-template domain and at least one other RNA structural motif separate from the template-containing domain.