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NB 506

Known as: NB-506 
National Institutes of Health

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4 relations

Broader (4)

Antineoplastic AgentsCarbazolesEnzyme InhibitorsGlucosides

Papers overview

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2000
2000
NB‐506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA
Review
2000
Review
2000
Preclinical and Clinical Trials of Topoisomerase Inhibitors
Abstract: CPT‐11, developed by Yakult Honsha, has achieved the position of standard chemotherapy for colorectal cancer in the… 
2000
2000
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
1999
1999
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
The antitumor drug NB-506, which is currently undergoing phase I/II clinical trials, contains a DNA-intercalating indolocarbazole… 
Highly Cited
1999
Highly Cited
1999
Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.
J-107088 [6-N-(1-hydroxymethyl-2-hydroxy)ethylamino-12,13-dihydro-2,10-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a… 
1999
1999
Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.
The DNA-intercalating antitumor drug NB-506 is a potent topoisomerase poison currently undergoing phase I/II clinical trials. It… 
1999
1999
In vivo Anti‐tumor Activity of a Novel Indolocarbazole Compound, J‐107088, on Murine and Human Tumors Transplanted into Mice
J‐107088 (6‐N‐(1‐hydroxymethyl‐2‐hydroxy)ethylamino‐12,13‐dihydro‐2,10‐dihydroxy‐13‐(β‐D‐glu‐copyranosyl)‐5H‐indolo[2,3‐a… 
Highly Cited
1996
Highly Cited
1996
Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.
Topoisomerase I-targeting anticancer agents such as 7-ethyl-10-[4-(1-piperidyl)-1-piperidyl]carbonyloxy-camptothecin (CPT-11) and… 
1996
1996
Antimetastatic Effect of a Novel Indolocarbazole (NB‐506) on IMC‐HM Murine Tumor Cells Metastasized to the Liver
IMC‐HM cells were isolated from spontaneously induced ascitic IMC carcinoma cells that had been maintained intraperitoneally in… 
1995
1995
Antitumor activities of a new indolocarbazole substance, NB-506, and establishment of NB-506-resistant cell lines, SBC-3/NB.
The novel anticancer glucosyl derivative of indolo-carbazole (NB-506), an inhibitor of DNA topoisomerase I, exhibited strong in… 
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