Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
- H. Hirai, Y. Iwasawa, H. Kotani
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 November 2009
The discovery of a potent and selective small-molecule inhibitor of Wee1 kinase, MK-1775, and its data indicate that Wee1 inhibition provides a new approach for treatment of multiple human malignancies.
Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells.
- A. Okura, H. Arakawa, H. Oka, T. Yoshinari, Y. Monden
- Biology, MedicineBiochemical and Biophysical Research…
- 30 November 1988
Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with…
- H. Komatani, H. Kotani, S. Nishimura
- BiologyCancer Research
- 1 April 2001
A novel mechanism of drug resistance mediated by BCRP is presented, suggesting the involvement of breast cancer resistant protein (BCRP) in the resistance and efflux of these drugs.
CMAP: a novel cystatin-like gene involved in liver metastasis.
- M. Morita, N. Yoshiuchi, H. Arakawa, S. Nishimura
- Biology, MedicineCancer Research
- 1999
A novel metastasis-associated gene was identified with a differential display system in murine carcinoma cells showing a high rate of metastasis to the liver, indicating that CMAP is involved in liver metastatic ability after intravasation of malignant cells.
In vivo Anti‐tumor Activity of a Novel Indolocarbazole Compound, J‐107088, on Murine and Human Tumors Transplanted into Mice
- H. Arakawa, M. Morita, S. Nishimura
- Chemistry, BiologyJapanese journal of cancer research : Gann
- 1 October 1999
J‐107088 was found to be highly effective in inhibiting proliferation of micro‐metastases of tumors to the liver in mice and is considered to be a promising candidate as an anti‐tumor drug for treatment of solid tumors in humans.
Identification and cloning of a novel isoform of mouse secretory leukocyte protease inhibitor, mSLPI-beta, overexpressed in murine leukemias and a highly liver metastatic tumor, IMC-HA1 cells.
- M. Morita, H. Arakawa, S. Nishimura
- BiologyAdvances in Enzyme Regulation
- 1 July 1999
Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c]carbazole- 5,7(6H)-dione (NB-506): its potent antitumor…
- H. Arakawa, T. Iguchi, S. Nishimura
- Chemistry, BiologyCancer Research
- 15 March 1995
Repeated injections of NB-506 had a stronger antitumor effect than intermittent injections in mice with MKN-45, and is considered to be an interesting possible candidate as an anticancer drug for treatment of solid tumors in humans.
Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of…
- T. Yoshinari, M. Matsumoto, S. Nishimura
- Chemistry, BiologyCancer Research
- 15 March 1995
NB-506 is a potent topoisomerase I poison, acting selectively on tumor cell lines accumulating NB-506, and its cytotoxicity was found to be cell line selective.
A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.
- K. Kojiri, H. Kondo, M. Okanishi
- BiologyJournal of antibiotics (Tokyo. )
- 25 July 1991
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.
- T. Yoshinari, M. Ohkubo, S. Nishimura
- Chemistry, BiologyCancer Research
- 1 September 1999
J-107088 induced single-strand DNA cleavage only in the presence of topoisomerase I (top1) more effectively than NB-506 or camptothecin, and may be relevant to its more potent in vivo antitumor efficacy in a human tumor xenographted nude mouse model.
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