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Stability and kinetics of G-quadruplex structures
An overview of recent literature on the structure and stability of unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo function and the unifying theme in this review is energetics.
Thermal difference spectra: a specific signature for nucleic acid structures
- J. Mergny, Jing Li, L. Lacroix, S. Amrane, J. Chaires
- ChemistryNucleic acids research
- 12 September 2005
TDS provides a simple, inexpensive and rapid method to obtain structural insight into nucleic acid structures, which is applicable to both DNA and RNA from short oligomers to polynucleotides.
Sequence and structural selectivity of nucleic acid binding ligands.
The sequence and structural selectivity of 15 different DNA binding agents was explored using a novel, thermodynamically rigorous, competition dialysis procedure, and selective agents showed in many cases less dramatic binding selectivity than anticipated from published reports that compared their binding to only a few structural forms.
Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: mode and specificity of binding.
The results of these studies indicated that both isomers bind to DNA by a single mode, but the two isomers differ, however, in their effect on the hydrodynamic properties of DNA as measured by viscosity and, therefore, probably differ in their individual binding modes.
Folding and unfolding pathways of the human telomeric G-quadruplex.
Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acid.
We have used equilibrium dialysis and fluorescence and absorbance titration to study the interaction of daunomycin with DNA. Our data at 200 mM Na+ are best fit by the neighbor exclusion model, with…
Energetics of drug-DNA interactions.
- J. Chaires
- Chemistry, BiologyBiopolymers
A perspective is offered on the interpretation of these thermodynamics parameters, and in particular how they might be correlated with known structural features on the drug-DNA binding process.
Calorimetry outside the box: a new window into the plasma proteome.
The difference in thermograms between normal and diseased individuals is not caused by radical changes in the concentrations of the most abundant plasma proteins but rather appears to result from interaction of as yet unknown biomarkers with the major plasma proteins.
A thermodynamic signature for drug-DNA binding mode.
- J. Chaires
- Chemistry, BiologyArchives of biochemistry and biophysics
- 1 September 2006
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
The results of biophysical experiments in solution and computational studies that are inconsistent with the reported crystal structure suggest that the biologically relevant structure of the human telomere quadruplex in K+ solution is not the one determined in the published crystalline state.