Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells.
- A. Okura, H. Arakawa, H. Oka, T. Yoshinari, Y. Monden
- Biology, MedicineBiochemical and Biophysical Research…
- 30 November 1988
Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c]carbazole- 5,7(6H)-dione (NB-506): its potent antitumor…
- H. Arakawa, T. Iguchi, S. Nishimura
- Chemistry, BiologyCancer Research
- 15 March 1995
Repeated injections of NB-506 had a stronger antitumor effect than intermittent injections in mice with MKN-45, and is considered to be an interesting possible candidate as an anticancer drug for treatment of solid tumors in humans.
Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of…
- T. Yoshinari, M. Matsumoto, S. Nishimura
- Chemistry, BiologyCancer Research
- 15 March 1995
NB-506 is a potent topoisomerase I poison, acting selectively on tumor cell lines accumulating NB-506, and its cytotoxicity was found to be cell line selective.
A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.
- K. Kojiri, H. Kondo, M. Okanishi
- BiologyJournal of antibiotics (Tokyo. )
- 25 July 1991
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.
- T. Yoshinari, M. Ohkubo, S. Nishimura
- Chemistry, BiologyCancer Research
- 1 September 1999
J-107088 induced single-strand DNA cleavage only in the presence of topoisomerase I (top1) more effectively than NB-506 or camptothecin, and may be relevant to its more potent in vivo antitumor efficacy in a human tumor xenographted nude mouse model.
Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.
- C. Bailly, L. Dassonneville, T. Yoshinari
- Biology, ChemistryCancer Research
- 15 June 1999
It is shown that a regio-isomeric form of NB-506 has lost its capacity to intercalate into DNA, but remains an extremely potent topoisomerase I poison, and the newly designed drug is considerably (up to 100-fold) more toxic to tumor cells than the parent drug.
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
- C. Bailly, X. Qu, T. Yoshinari
- Chemistry, BiologyJournal of Medicinal Chemistry
- 29 July 1999
The results suggest that the antitumor activity of indolocarbazole-based drugs can be enhanced by incorporating DNA and/or topoisomerase I reactive groups and support the hypothesis that the substituent on the imide nitrogen on the F ring of NB-506 has direct interaction with the molecular target.
A new topoisomerase-II inhibitor, BE-10988, produced by a streptomycete. I. Taxonomy, fermentation, isolation and characterization.
- H. Oka, T. Yoshinari, Y. Shizuri
- BiologyJournal of antibiotics (Tokyo. )
- 25 May 1991
A new topoisomerase inhibitor, BE-10988, was isolated from the culture broth of a strain of actinomycetes and inhibited the growth of both doxorubicin-resistant and vincristine-resistant P388 murine leukemia cell lines, as well as sensitive P388 cell lines.
Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110.
- T. Yoshinari, A. Yamada, A. Okura
- Biology, ChemistryCancer Research
- 1 February 1993
Results suggest that ED-110 has potential as a novel antitumor agent targeting topoisomerase I, which is distinguished from camptothecin by its very different structure and its ability to intercalate into double-stranded DNA.
A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity.
A new topoisomerase II inhibitor, designated BE-22179, was isolated from the culture broth of Streptomyces sp. A22179, which resembles "Streptomyces gangtokensis". The inhibitor was extracted from…
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