• Publications
  • Influence
Strategies and challenges for the next generation of therapeutic antibodies
TLDR
Strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions are discussed. Expand
Anti‐proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: Implication of epidermal growth factor receptor down‐regulation and ceramide production
Anandamide (ANA) is an endogenous lipid which acts as a cannabinoid receptor ligand and with potent anticarcinogenic activity in several cancer cell types.
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.
TLDR
Ecteinascidin 743 retarded the electrophoretic migration of both supercoiled and relaxed simian virus 40 DNA even in the presence of sodium dodecyl sulfate and after ethanol precipitation, consistent with covalent DNA modifications. Expand
Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
TLDR
It is concluded that triptolide is an original pharmacologic inhibitor of RNA polymerase activity, affecting indirectly the transcription machinery, leading to a rapid depletion of short-lived mRNA, including transcription factors, cell cycle regulators, and the oncogenes MYC and Src. Expand
Ready for a comeback of natural products in oncology.
  • C. Bailly
  • Medicine
  • Biochemical pharmacology
  • 1 May 2009
TLDR
Observations plead for the return of natural products in oncology with the approval of three new drugs derived from natural products, the emergence of promising antitumor compounds from microorganisms and the growing importance of new formulations of known natural product-derived drugs. Expand
Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants
  • Jean-Marie Péloponèse, Yves Collette, +5 authors Erwann P. Loret
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 23 April 1999
TLDR
The results indicate that the high virulence of some African HIV-1 strains could be related to Tat activity, and these Tat synthetic proteins cross membranes but differ in their ability to trans-activate an HIV LTR-reporter gene in stably transfected HeLa cells. Expand
Role of the Multidrug Efflux System MexXY in the Emergence of Moderate Resistance to Aminoglycosides among Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis
TLDR
Data indicate that a locus different from mexZ may be involved in overproduction of MexXY and that other nonenzymatic mechanisms contribute to AG resistance in P. aeruginosa. Expand
Topoisomerase I poisons and suppressors as anticancer drugs.
  • C. Bailly
  • Chemistry, Medicine
  • Current medicinal chemistry
  • 2000
TLDR
This review is concerned with the different families of topoisomerase I poisons and suppressors, which constitute a novel family of antitumor agents and their origin, chemical nature and mechanism of action. Expand
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
TLDR
Direct evidence is provided that DNA is the primary target of cryptolepine and it is suggested that this alkaloid is a valid candidate for the development of tumor active compounds. Expand
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