Mitogen-Activated Protein Kinase 12

Systemic signalling is indispensable for the coordination of diverse physiological processes during development, defence and… (More)

X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal… (More)

The differentiation of C2C12 myoblasts to myotubes was found to be accompanied by a strong activation of p70 S6 kinase and the… (More)

Mechanisms for selective targeting to unique subcellular sites play an important role in determining the substrate specificities… (More)

BACKGROUND Specific inhibitors of protein kinases have great therapeutic potential, but the molecular basis underlying their… (More)

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase compete with ATP for binding. Mutation of 23 residues in… (More)

Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution… (More)

A novel homologue of p38 MAP kinase, called SAPK4, has been cloned which shares 61% amino acid identity with p38 and is expressed… (More)

The paired helical filament, which comprises the major fibrous element of the neurofibrillary lesions of Alzheimer's disease, is… (More)

A cDNA was cloned that encodes human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino acid… (More)