• Publications
  • Influence
Neurodegenerative tauopathies.
TLDR
Emerging data support the hypothesis that different tau gene mutations are pathogenic because they impair tau functions, promote tau fibrillization, or perturb tAU gene splicing, thereby leading to formation of biochemically and structurally distinct aggregates of tau.
α-Synuclein in Lewy bodies
TLDR
Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TLDR
It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
TLDR
The results show that dysregulation of tau protein production can cause neurodegeneration and imply that the FTDP-17 gene is the tau gene, which has major implications for Alzheimer's disease and other tauopathies.
A Century of Alzheimer's Disease
TLDR
The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis.
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
TLDR
It is shown thatLewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of alpha-synuclein, showing the presence of full- length or close to full-length alpha- synuclein.
Transmission and spreading of tauopathy in transgenic mouse brain
TLDR
Transgenic mice expressing mutant (for example, P301S) human tau in nerve cells show the essential features of tauopathies, including neurodegeneration and abundant filaments made of hyperphosphorylated tau protein.
Alpha-synuclein and neurodegenerative diseases
  • M. Goedert
  • Biology, Medicine
    Nature Reviews Neuroscience
  • 1 July 2001
TLDR
The molecular properties of the synucleins, the different diseases characterized by the accumulation of α-synuclein, and the possible mechanisms by which dysfunction ofα- synuclein might lead to neurodegeneration are reviewed.
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