• Publications
  • Influence
State-dependent opioid control of pain
  • H. Fields
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 1 July 2004
There is growing evidence that the state of the circuit is determined by aversive and appetitive motivational states, and that this contributes to adaptive behavioural choice.
Neurotransmitters in nociceptive modulatory circuits.
The similarity in response properties among the members of each class, their large, somatic "receptive fields," and the wide distribution of the terminal fields of axons of individual neurons to the trigeminal sensory complex and to multiple spinal segments indicate that these neurons exert a global influence over nociceptive responsiveness.
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
It is concluded that reliable physiological criteria for VTA DA neuron identification have yet to be determined, and that the criteria currently being used are unreliable.
The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
Evidence is provided indicating that neurons in the ACC are necessary for the “aversiveness” of nociceptor stimulation by measuring a learned behavior that directly reflects the affective component of pain in the rat.
Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement.
Identifying the neurotransmitter content and projection target of VTA neurons recorded in vivo will be critical for determining their contribution to learned appetitive behaviors.
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex.
It is demonstrated that DA release in specific brain regions can be independently regulated by opioid targeting of a subpopulation of VTA DA neurons, with important implications for understanding addiction, attention disorders, and schizophrenia.
The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat
It is proposed that off- cells must pause if the tail flick is to occur, and that this pausing allows the transmission of nociceptive input through spinal reflex loops.