• Publications
  • Influence
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
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Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
Dopamine neurons in the ventral tegmental area (VTA) represent a critical site of synaptic plasticity induced by addictive drugs. Orexin/hypocretin-containing neurons in the lateral hypothalamusExpand
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The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
The ventral tegmental area (VTA) and in particular VTA dopamine (DA) neurons are postulated to play a central role in reward, motivation and drug addiction. However, most evidence implicating VTA DAExpand
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Neurotransmitters in nociceptive modulatory circuits.
Significant advances have been made in our understanding of nociceptive modulation from RVM. Among the most useful conceptually has been the discovery that there are two classes of modulatory neuronsExpand
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The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses
Separate studies have implicated the lateral habenula (LHb) or amygdala-related regions in processing aversive stimuli, but their relationships to each other and to appetitive motivational systemsExpand
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  • Open Access
The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
Numerous human and animal studies indirectly implicate neurons in the anterior cingulate cortex (ACC) in the encoding of the affective consequences of nociceptor stimulation. No causal evidence,Expand
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  • Open Access
Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement.
Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive sensory cues and scales with the magnitude and unpredictability of received rewards. These patterns areExpand
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  • Open Access
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex.
Dopaminergic afferents arising from the ventral tegmental area (VTA) are crucial elements in the neural circuits that mediate arousal, motivation, and reinforcement. Two major targets of theseExpand
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  • Open Access
The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat
Neurons of the rostral ventromedial medulla (RVM) have been implicated in the modulation of nociceptive transmission. In order to further analyze their role in pain behavior, we studied theirExpand
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  • Open Access
Corticostriatal functional connectivity predicts transition to chronic back pain
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When painExpand
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