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Central modulation of pain.
Evidence for "top-down" modulatory circuits that profoundly change the sensory experience of pain is reviewed. Expand
Chronic pain and medullary descending facilitation
The likelihood that sustained activation of descending modulatory pathways that facilitate pain transmission could underlie some states of chronic pain is examined. Expand
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats, demonstrating a mechanism leading to the inhibition of pain, one that targets receptors localized exclusively outside the CNS. Expand
Unmasking the tonic-aversive state in neuropathic pain
Conditioned place preference is used to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it and provides a new approach for investigating tonicPain in animals and for evaluating the analgesic effects of drugs. Expand
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
Test the hypothesis that CB(2) receptor activation stimulates release from keratinocytes of the endogenous opioid beta-endorphin, which then acts at local neuronal mu-opioid receptors to inhibit nociception and indicates anatomical specificity of opioid effects. Expand
Distinct potassium channels on pain-sensing neurons
It is found nerve injury induced by the Chung model of neuropathic pain leads to striking reductions in voltage-gated K+ (Kv) channel subunit expression in dorsal root ganglia (DRG) neurons, suggesting a potential molecular mechanism for hyperexcitability of injured nerves. Expand
AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties
AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain. Expand
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.
The present study has investigated the pharmacology of SNC 80, a nonpeptidic ligand proposed to be a selective delta agonist in vitro and in vivo. SNC 80 was potent in producing inhibition ofExpand
CB2 cannabinoid receptor-mediated peripheral antinociception
Using AM1241, a CB2 receptor‐selective agonist, it is demonstrated that CB2 receptors produce antinociception to thermal stimuli and the local, peripheral nature of CB2 cannabinoid antinOCiception is demonstrated. Expand
Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain
The data indicate that these time-dependent descending influences can underlie some of the SNL-induced plasticity at the spinal level and are key elements in the maintenance, but not initiation, of neuropathic states. Expand