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Mice, Inbred NOD

Known as: Non Obese Diabetic Mice, Diabetic Mice, Non-Obese, Non Obese Diabetic Mouse 
A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent… 
National Institutes of Health

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Diabetes MellitusDiabetes Mellitus, ExperimentalDiabetes Mellitus, Insulin-DependentIn Blood

Broader (1)

Laboratory mice

Papers overview

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Highly Cited
2000
Highly Cited
2000
Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of…
We describe a tolerance-based stem cell transplantation protocol that combines sublethal radiation with transient blockade of the… 
Highly Cited
1999
Highly Cited
1999
Evidence that beta cell death in the nonobese diabetic mouse is Fas independent.
Recent studies suggest that Fas expression on pancreatic beta cells may be important in the development of autoimmune diabetes in… 
Highly Cited
1997
Highly Cited
1997
Deviation of pancreas‐infiltrating cells to Th2 by interleukin‐12 antagonist administration inhibits autoimmune diabetes
Nonobese diabetic (NOD) mice develop spontaneous insulin‐dependent diabetes mellitus (IDDM), and the pancreas‐infiltrating T… 
Highly Cited
1995
Highly Cited
1995
IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.
Insulin-dependent diabetes mellitus in nonobese diabetic (NOD) mice results from selective destruction of pancreatic islet beta… 
Highly Cited
1993
Highly Cited
1993
Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease
How peptide-major histocompatibility complex (MHC) class II complexes are naturally generated is still unknown, but accumulating… 
Highly Cited
1991
Highly Cited
1991
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice
Five islet-reactive T cell clones were established from islet- infiltrating T cells of non-obese diabetic (NOD) mice. All clones… 
Highly Cited
1982
Highly Cited
1982
Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini.
The nature and mechanism of the pancreatic exocrine dysfunction in diabetes mellitus were evaluated in vitro using isolated… 
Highly Cited
1980
Highly Cited
1980
COMPLEMENT-FIXING ISLET-CELL ANTIBODIES IN TYPE-I DIABETES: POSSIBLE MONITORS OF ACTIVE BETA-CELL DAMAGE
Highly Cited
1980
Highly Cited
1980
Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus.
We studied serum from 36 patients with insulin-dependent diabetes mellitus (IDDM) for the capacity to lyse beta cells… 
Highly Cited
1968
Highly Cited
1968
The Sorbitol Pathway: Enzyme Localization and Content in Normal and Diabetic Nerve and Cord
The enzymes of the sorbitol pathway, aldose reductase and sorbitol dehydrogenase, were investigated in sciatic nerve and spinal… 
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