• Publications
  • Influence
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy.
TLDR
Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated. Expand
Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation.
TLDR
It is suggested that sustained single nephron hyperfiltration may have maladaptive consequences by damaging remnant glomeruli and alterations in glomerular hemodynamics associated with renal ablation are accompanied by structural lesions. Expand
Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal
TLDR
With the development and increasingly widespread availability of dialysis and transplantation in the past three decades, relatively little attention has been paid to the influence of diet on the progression of renal disease, despite general awareness that renal disease typically follows an inexorably progressive course. Expand
Diverse biological actions of atrial natriuretic peptide.
TLDR
Synthese sur son mecanisme d'action cellulaire et ses organes cibles: systeme cardiovasculaire, rein, surrenales et fonctions endocrines, Role du peptide dans le disfonctionnement cardiaque, l'hypertension, les maladies hepatiques et renales. Expand
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.
TLDR
In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years. Expand
Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.
TLDR
Prevention of glomerular capillary hypertension in rats with diabetes mellitus effectively protects against the subsequent development ofglomerular structural injury and proteinuria, further supporting the view that hemodynamic rather than metabolic factors predominate in the pathogenesis of diabetic glomerulopathy. Expand
The hyperfiltration theory: a paradigm shift in nephrology.
TLDR
Clinical studies indicate that dietary protein restriction and antihypertensive therapy also slow progression in many of these disorders, including diabetes mellitus, solitary or remnant kidneys, and various forms of acquired renal disease. Expand
Glomeruli and blood pressure. Less of one, more the other?
TLDR
It is postulate that a renal abnormality that contributes to essential hypertension in the general population is a reduced number of nephrons, and congenital variability in filtration surface area may explain why only some, but not all, patients exposed to potentially injurious renal stimuli eventually manifest chronic nephropathy. Expand
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
TLDR
The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. Expand
...
1
2
3
4
5
...