TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

@article{Belghith2003TGFdependentMM,
  title={TGF-$\beta$-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes},
  author={Meriam Belghith and Jeffrey A. Bluestone and Samia Barriot and Jérôme Mégret and Jean François Bach and Lucienne Chatenoud},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1202-1208}
}
CD3-specific antibodies have the unique capacity to restore self-tolerance in established autoimmunity. They induce long-term remission of overt diabetes in nonobese diabetic (NOD) mice and in human type I diabetes. The underlying mechanisms had been unclear until now. Here we report that treatment with CD3ε-specific antibodies induces transferable T-cell-mediated tolerance involving CD4+CD25+ cells. However, these CD4+CD25+ T cells are distinct from naturally occurring regulatory T cells that… 
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