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Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses
Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss
A synonymous single-nucleotide polymorphism in exon 7 of Cdh23 that shows significant association with AHL and the deafness modifier mdfw (modifer of deafwaddler) is found.
Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent
Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.
The Ush1c mutant mice described here provide a means to directly investigate protein interactions in vivo and to evaluate gene structure-function relationships that affect inner ear and eye phenotypes, as well as to mapped two new recessive mutations causing circling behavior and deafness to the same region on chromosome 7.
A major gene affecting age-related hearing loss in C57BL/6J mice
Intestinal Brush Border Assembly Driven by Protocadherin-Based Intermicrovillar Adhesion
An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis
Results indicate that hBD-3 utilizes CCR2 to regulate monocyte/macrophage trafficking and may act as a tumor cell-produced chemoattractant to recruit TAMs, demonstrating the importance of the innate immune system in the development of tumors.
A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.
It is shown that the same Chromosome 10 gene (Ahl) is a major contributor to AHL in nine other inbred mouse strains-129P1/ReJ, A/J, BALB/cByJ, BUB/BnJ, C57BR/cdJ, DBA/2J, NOD/LtJ, SKH2/j, and STOCK760.
Age-related hearing loss and the ahl locus in mice