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Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).
Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. A simple definition and classificationExpand
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Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program.
BACKGROUND Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment ofExpand
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Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation.
Micropuncture studies were performed in three groups of male Munich-Wistar rats 1 wk after surgery: group I, eight control rats that underwent laparotomy and were fed a normal diet; group II, nineExpand
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Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal
IT is now more than 30 years since Addis suggested that protein intake be restricted in patients with chronic renal insufficiency.1 His aim was not to reduce uremic symptoms but rather to prevent anExpand
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Glomerular hemodynamics in experimental diabetes mellitus.
Micropuncture studies were performed in three groups of euvolemic male Munich-Wistar rats: 8 control rats, 7 severely hyperglycemic rats made diabetic with streptozotocin (60 mg/kg, i.v.), and 6Expand
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Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration.
Changes in proteinuria have been suggested as a surrogate outcome for kidney disease progression to facilitate the conduct of clinical trials. This report summarizes a workshop sponsored by theExpand
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K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease.
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Molecular mechanisms of diabetic kidney disease.
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease of gene andExpand
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Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000.
The incidence of kidney failure treatment in the United States increased 57% from 1991 to 2000. Chronic kidney disease (CKD) prevalence was 11% among U.S. adults surveyed in 1988 to 1994. TheExpand
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Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development
BackgroundOne in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate thatExpand
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