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Methapyrilene

Known as: Thenylpyramine, 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine, N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine 
Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
National Institutes of Health

Related topics

Related topics

21 relations
Angle Closure GlaucomaDrug AllergyHistamine H1 Receptor Antagonists [MoA]In Blood

Broader (3)

Anti-Allergic AgentsHistamine H1 AntagonistsHypnotics and Sedatives

Narrower (5)

DorminMETHAPYRILENE HYDROCHLORIDEchlorothenmethafurylene

Papers overview

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1989
1989
Characterization of the antihistamines tripelennamine, methapyrilene, and thenyldiamine and their N-oxides by thermospray mass spectrometry.
This study describes an investigation of the thermospray (TS) mass spectrometric analysis of tripelennamine, methapyrilene… 
1988
1988
Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives.
1. Strains of the fungus Cunninghamella elegans ATCC 9245 and 36112 were tested for their ability to transform the antihistamines… 
1985
1985
Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene.
Abstract Although methapyrilene (MP) produces hepatocellular carcinomas in rats, it does not elicit many of the cellular… 
1982
1982
Methapyrilene effects on initiation and promotion of gamma-glutamyl-transpeptidase positive foci in rat liver.
The initiating and promoting effects of methapyrilene were evaluated using the hepatic enzyme-altered foci bioassay. Male Sprague… 
1981
1981
Morphology of early changes in liver carcinogenesis induced by methapyrilene
Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal… 
Highly Cited
1981
Highly Cited
1981
Characterization of DNA repair elicited by carcinogens and drugs in the hepatocyte primary culture/DNA repair test.
The autoradiographic unscheduled DNA synthesis measured in the hepatocyte primary culture/DNA repair test after exposure to… 
Highly Cited
1974
Highly Cited
1974
Drug release from hydroxypropyl cellulose-polyvinyl acetate films.
The release of methapyrilene, pentobarbital, and salicylic acid dispersed in films composed of different ratios of hydroxypropyl… 
1969
1969
Chromatographic analysis of chlorpheniramine, pyrilamine, and methapyrilene in combination.
A partition chromatographic method is presented for the separation and quantitation of chlorpheniramine, methapyrilene, and… 
1966
1966
Some physicochemical properties of the montmorillonites.
The swelling, moisture sorption, particle size, cation-exchange, and drug adsorption properties of selected montmorillonites were… 
1959
1959
A note on the crystallography of thenylpyramine hydrochloride.