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Methapyrilene

Known as: Thenylpyramine, 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine, N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine 
Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
National Institutes of Health

Related topics

Related topics

21 relations
Angle Closure GlaucomaDrug AllergyHistamine H1 Receptor Antagonists [MoA]In Blood

Broader (3)

Anti-Allergic AgentsHistamine H1 AntagonistsHypnotics and Sedatives

Narrower (5)

DorminMETHAPYRILENE HYDROCHLORIDEchlorothenmethafurylene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium.
Review
2008
Review
2008
Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.
The present study was conducted as a model case of the toxicogenomics approach for analyzing toxicological mechanisms and… 
Review
1996
Review
1996
Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens.
1995
1995
The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study.
Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma… 
1992
1992
Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes.
1. Suspension cultures of freshly isolated F344 rat and B6C3F1 mouse hepatocytes were compared for their ability to transform… 
1988
1988
Lack of binding of methapyrilene and similar antihistamines to rat liver DNA examined by 32P postlabeling.
The nonmutagenic carcinogen methapyrilene, together with several noncarcinogenic analogues, was administered to rats p.o. for as… 
1988
1988
Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives.
1. Strains of the fungus Cunninghamella elegans ATCC 9245 and 36112 were tested for their ability to transform the antihistamines… 
Highly Cited
1984
Highly Cited
1984
Histamine Stimulation of Inositol 1‐Phosphate Accumulation in Lithium‐Treated Slices from Regions of Guinea Pig Brain
Abstract: Histamine stimulated the accumulation of [3H]inositol 1‐phosphate in the presence of 10 mM LiCl in [3H]inositol‐loaded… 
Highly Cited
1983
Highly Cited
1983
Involvement of lipoxygenase products in myometrial contractions.
1981
1981
Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of methapyrilene.
The popular antihistamine methapyrilene [N,N-dimethyl-N'-(2-pyridyl)-N'-(2-thienylmethyl)-1,2-ethanediamine] recently has been… 
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