Methapyrilene

Known as: Thenylpyramine, 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine, N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine 
Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Administration of high doses of the histamine antagonist methapyrilene to rats causes periportal liver necrosis. The mechanism of… (More)
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Highly Cited
2005
Highly Cited
2005
Application of recently developed gene expression techniques using microarrays in toxicological studies (toxicogenomics… (More)
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2004
2004
Several studies using microarrays have shown that changes in gene expression provide information about the mechanism of toxicity… (More)
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2002
2002
Methapyrilene (MP) exposure of animals can result in an array of adverse pathological responses including hepatotoxicity. This… (More)
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Highly Cited
2001
Highly Cited
2001
A rate-limiting step that occurs in the drug discovery process is toxicological evaluation of new compounds. New techniques that… (More)
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Highly Cited
2001
Highly Cited
2001
Microarray technology, which allows one to quantitate the expression of thousands of genes simultaneously, has begun to have a… (More)
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2000
2000
The mechanisms by which acute administration of methapyrilene, an H(1)-receptor antihistamine causes periportal necrosis to rats… (More)
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1985
1985
Short-term treatment of rats with hepatocarcinogens elicits a consistent pattern of phenotypic changes in hepatic drug… (More)
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1981
1981
Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal… (More)
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1975
1975
The antihistamines diphenhydramine and methapyrilene were compared with pentobarbital for hypnotic effect in two Veterans… (More)
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