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- Publications
- Influence
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
- Warwick B. Dunn, D. Broadhurst, +11 authors R. Goodacre
- Chemistry, Medicine
- Nature Protocols
- 1 June 2011
Metabolism has an essential role in biological systems. Identification and quantitation of the compounds in the metabolome is defined as metabolic profiling, and it is applied to define metabolic… Expand
Global metabolic profiling procedures for urine using UPLC–MS
- E. Want, I. Wilson, +5 authors J. Nicholson
- Chemistry, Medicine
- Nature Protocols
- 1 June 2010
The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations in response to physiological… Expand
Rapid and noninvasive metabonomic characterization of inflammatory bowel disease.
- J. Marchesi, E. Holmes, +5 authors Yulan Wang
- Medicine
- Journal of proteome research
- 4 January 2007
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and populations. Accurate diagnosis of inflammatory bowel… Expand
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
- J. Swann, E. Want, +5 authors E. Holmes
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 13 September 2010
We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver, kidney, heart, and blood plasma) in rats. We use a targeted… Expand
Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum.
- E. Zelená, Warwick B. Dunn, +8 authors D. Kell
- Chemistry, Medicine
- Analytical chemistry
- 15 February 2009
A method for performing untargeted metabolomic analysis of human serum has been developed based on protein precipitation followed by Ultra Performance Liquid Chromatography and Time-of-Flight mass… Expand
Analytical strategies in metabonomics.
To perform metabonomics investigations, it is necessary to generate comprehensive metabolite profiles for complex samples such as biofluids and tissue/tissue extracts. Analytical technologies that… Expand
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans.
- W. Dunn, I. Wilson, A. Nicholls, D. Broadhurst
- Computer Science, Medicine
- Bioanalysis
- 9 October 2012
TLDR
UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.
- R. Plumb, K. A. Johnson, +4 authors J. Nicholson
- Chemistry, Medicine
- Rapid communications in mass spectrometry : RCM
- 15 July 2006
A new approach to obtain fragmentation information in liquid chromatography/mass spectrometry (LC/MS) studies of small molecules in complex mixtures is presented using simultaneous acquisition of… Expand
Liquid chromatography-mass spectrometry based global metabolite profiling: a review.
- G. Theodoridis, H. Gika, E. Want, I. Wilson
- Chemistry, Medicine
- Analytica chimica acta
- 20 January 2012
Untargeted, global metabolite profiling (often described as metabonomics or metabolomics) represents an expanding research topic and is, potentially, a major pillar for systems biology studies. To… Expand
Global metabolic profiling of animal and human tissues via UPLC-MS
- E. Want, Perrine Masson, +7 authors J. Nicholson
- Chemistry, Medicine
- Nature Protocols
- 2013
Obtaining comprehensive, untargeted metabolic profiles for complex solid samples, e.g., animal tissues, requires sample preparation and access to information-rich analytical methodologies such as… Expand