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Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
Metabolism has an essential role in biological systems. Identification and quantitation of the compounds in the metabolome is defined as metabolic profiling, and it is applied to define metabolicExpand
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Global metabolic profiling procedures for urine using UPLC–MS
The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations in response to physiologicalExpand
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Rapid and noninvasive metabonomic characterization of inflammatory bowel disease.
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and populations. Accurate diagnosis of inflammatory bowelExpand
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Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
  • J. Swann, E. Want, +5 authors E. Holmes
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 13 September 2010
We elucidate the detailed effects of gut microbial depletion on the bile acid sub-metabolome of multiple body compartments (liver, kidney, heart, and blood plasma) in rats. We use a targetedExpand
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Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum.
A method for performing untargeted metabolomic analysis of human serum has been developed based on protein precipitation followed by Ultra Performance Liquid Chromatography and Time-of-Flight massExpand
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Analytical strategies in metabonomics.
  • E. Lenz, I. Wilson
  • Chemistry, Medicine
  • Journal of proteome research
  • 1 February 2007
To perform metabonomics investigations, it is necessary to generate comprehensive metabolite profiles for complex samples such as biofluids and tissue/tissue extracts. Analytical technologies thatExpand
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The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans.
The metabolic investigation of the human population is becoming increasingly important in the study of health and disease. Expand
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UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.
A new approach to obtain fragmentation information in liquid chromatography/mass spectrometry (LC/MS) studies of small molecules in complex mixtures is presented using simultaneous acquisition ofExpand
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Liquid chromatography-mass spectrometry based global metabolite profiling: a review.
Untargeted, global metabolite profiling (often described as metabonomics or metabolomics) represents an expanding research topic and is, potentially, a major pillar for systems biology studies. ToExpand
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Global metabolic profiling of animal and human tissues via UPLC-MS
Obtaining comprehensive, untargeted metabolic profiles for complex solid samples, e.g., animal tissues, requires sample preparation and access to information-rich analytical methodologies such asExpand
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