• Publications
  • Influence
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.
TLDR
Detailed electrophysiological characterization of highly pure hiPSC-derived cardiomyocytes concludes that they have ionic currents and channel gating properties underlying their APs and EADs that are quantitatively similar to those reported for human cardiac myocytes. Expand
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.
TLDR
It is demonstrated that gene expression events monitored in the liver can be used to predict pathological events occurring in that tissue as well as in hematopoietic tissues. Expand
The role of oxidative stress in chemical carcinogenesis.
TLDR
A potential role for oxidative-induced injury in the cancer process specifically during the promotion stage is supported and the effect of nongenotoxic carcinogens may be amplified in rodents but not in primates because of rodents' greater sensitivity to ROS. Expand
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes.
TLDR
The first published report of a high-throughput functional assay employing a monolayer of beating human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is described, detailing a model that accurately detects drug-induced cardiac abnormalities. Expand
Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
TLDR
It is hoped that a thorough understanding of the mechanisms underlying cardiotoxicity will lead to the development of safe, effective drugs and consequently, fewer costly surprises as agents progress through clinical trials. Expand
Induction of Cyp1a1 Is a Nonspecific Biomarker of Aryl Hydrocarbon Receptor Activation: Results of Large Scale Screening of Pharmaceuticals and Toxicants in Vivo and in Vitro
TLDR
It is demonstrated that induction of Cyp1a1 is a nonspecific biomarker of direct AhR affinity and activation and lend further support to the hypothesis that Cyp 1a1 induction and/or AhR activation is not synonymous with dioxin-like toxicity. Expand
Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.
TLDR
A patient-specific induced pluripotent stem cell (iPSC) model of a complex metabolic condition is presented, showing the power of this technique for discovery and testing of therapeutic strategies for a disease with ever-increasing clinical significance. Expand
Opportunities for Use of Human iPS Cells in Predictive Toxicology
TLDR
The properties of human induced pluripotent stem (iPS) cells that make them a promising source for toxicity assessment are described, the progress to date is highlighted, and the important roadblocks that remain are pointed out. Expand
A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity
TLDR
Genetic data can be more sensitive than traditional methods for the early prediction of compound-induced pathology in the kidney, demonstrating the enhanced sensitivity of gene expression relative to traditional approaches. Expand
Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats.
TLDR
The lack of an increase in serum enzymes indicative of hepatic damage and the absence of liver histopathology in mice or rats fed dieldrin or phenobarbital indicate that the induction of DNA synthesis was not mediated by a cytolethal, compensatory hyperplastic response, suggesting a mitogenic mechanism. Expand
...
1
2
3
4
5
...