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Pyrene degradation by a Mycobacterium sp.: identification of ring oxidation and ring fission products
TLDR
The degradation of pyrene by pure cultures of a Mycobacterium sp.
Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.
TLDR
Functional and biochemical data are presented demonstrating the presence of MRP in the brain microvessel endothelial cells that form the blood-brain barrier (BBB) and its function as a drug efflux transport system.
Role of High‐Affinity Dopamine Uptake and Impulse Activity in the Appearance of Extracellular Dopamine in Striatum After Administration of Exogenous L‐DOPA
TLDR
It is shown that DA synthesized from exogenous L‐DOPA primarily is released by an impulse‐dependent mechanism in both intact and DA‐denervated striatum, suggesting an important role for a nondopaminergic neuronal element in striatum that serves as the primary source of extracellular DA formed fromExogenous L-DOPA.
Reducing the length of time between slaughter and the secondary gonadotropin-releasing factor immunization improves growth performance and clears boar taint compounds in male finishing pigs.
TLDR
The study provides further evidence of the efficacy of the anti-GnRF immunization and indicates that the secondary immunization can be moved closer to slaughter, while still limiting the incidence of boar taint.
Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization.
TLDR
P85 accumulates in the cells and intracellular organelles such as the mitochondria where it can interfere with metabolic processes and both energy depletion and membrane fluidization are critical factors contributing to the activity of the block copolymer in the BBB.
Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.
TLDR
Results suggest that the TNF-alpha-induced permeability and cytoskeletal structural effects are due, in part, to an induction of the COX-2 system and increased release of prostaglandins in the cerebral microvasculature.
Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion
TLDR
It is demonstrated that exposure of cells to the poly(ethylene oxide)-poly(propylene oxide) block copolymer, Pluronic P85, results in a substantial decrease in ATP levels selectively in MDR cells.
Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.
TLDR
Data indicate that Pluronic P85 can enhance the delivery of digoxin to the brain through the inhibition of the P-glycoprotein-mediated efflux mechanism.
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