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METHAPYRILENE HYDROCHLORIDE

National Institutes of Health

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Angle Closure GlaucomaDrug AllergyHistamine H1 Receptor Antagonists [MoA]Methapyrilene

Papers overview

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2011
2011
An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity.
2004
2004
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats
SummaryFour histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in… 
1991
1991
The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation.
1988
1988
An interlaboratory evaluation of the Syrian hamster embryo cell transformation assay using eighteen coded chemicals.
1988
1988
The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats.
1984
1984
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Methapyrilene hydrochloride [2-[2-(dimethylamino)-ethyl)-2-thenylamino)pyridine monohydrochloride (CAS: 135-23-9)]-induced… 
1983
1983
Failure of methapyrilene to induce tumors in hamsters or guinea pigs.
In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage twice a week for 78 wk with a 200… 
Highly Cited
1982
Highly Cited
1982
Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens.
Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described… 
1982
1982
Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo.
The induction of sister chromatid exchanges (SCE) by the hepatocarcinogen methapyrilene hydrochloride was investigated using… 
1955
1955
Hypnotic effects of an antihistamine; methapyrilene hydrochloride.
Excerpt It is widely recognized that one of the important side effects of the antihistamines as a class is their sedative action… 
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