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Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
TLDR
Antibody-mediated blockade of PD-L1 induced durable tumor regression and prolonged stabilization of disease in patients with advanced cancers, including non-small-cell lung cancer, melanoma, and renal-cell cancer.
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A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.
TLDR
The FOLFOX regimen of oxaliplatin and infused fluorouracil plus leucovorin was active and comparatively safe and should be considered as a standard therapy for patients with advanced colorectal cancer.
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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be…
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Pathology of mouse models of intestinal cancer: consensus report and recommendations.
TLDR
This paper presents a poster presented at the 2015 American Academy of Pathology Congress, entitled “Advances in Pathology and Laboratory Medicine: Foundations of Precision Pathology, 2nd Ed.” in Cleveland, Ohio.
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Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients.
TLDR
The broad spectrum of carcinoid heart disease is detailed in this large series, which includes not only right-sided valvular lesions but also left-sided involvement, pericardial effusion, and myocardial metastases.
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Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase III trials N9741 and N9841.
PURPOSE Symptoms and complications of metastatic colorectal cancer (mCRC) differ by metastatic sites. There is a paucity of prospective survival data for patients with peritoneal carcinomatosis…
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Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer.
TLDR
Results of this trial suggest a benefit for EGFR/HER1 blockade with erlotinib in patients with HCC manifested by disease control.
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Capecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant Breast and Bowel Project trial R-04.
TLDR
Administering capecitabine with preoperative RT achieved similar rates of pCR, sphincter-sparing surgery, and surgical downstaging compared with CVI FU, and adding oxaliplatin did not improve surgical outcomes but added significant toxicity.
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Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations.
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Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene
TLDR
HPV-16 E7 can alter epithelial cell growth parameters sufficiently to potentiate tumorigenesis in mice, and this hypothesis that E6 and E7 contribute to cervical carcinogenesis is concluded.
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