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Methadyl Acetate

Known as: 6-(Dimethylamino)-4,4-Diphenyl-3-Heptanol Acetate, Methadyl Acetate [Chemical/Ingredient], Acetylmethadol 
A narcotic analgesic with a long onset and duration of action.
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (6)

1 alpha-acetyldinormethadolAlphacetylmethadolLevomethadyl AcetateLevomethadyl Acetate Hydrochloride

Broader (4)

Analgesics, OpioidMethadoneNarcotic Analgesicssynthetic opioids
In BloodLevomethadylagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel.
This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol… 
Highly Cited
2002
Highly Cited
2002
Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis.
Highly Cited
1997
Highly Cited
1997
The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.
The N-demethylation of LAAM, norLAAM, and methadone has been investigated in human liver microsomes and microsomes containing… 
1977
1977
Methadyl acetate and methadone. An open comparison.
Heroin addicts were recruited for a 14-week open clinical comparison of methadone hydrochloride and methadyl acetate. Patients… 
Highly Cited
1976
Highly Cited
1976
Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study.
This was a double-blind comparison of methadyl acetate and two dose levels of methadone hydrochloride in the maintenance of 430… 
Highly Cited
1975
Highly Cited
1975
Disposition of acetylmethadol in relation to pharmacologic action
The levels of acetylmethadol and its active biotransformation products were quantitated in the plasma and urine of subjects on… 
Highly Cited
1972
Highly Cited
1972
Methadyl acetate vs methadone. A double-blind study in heroin users.
Thirty-four long-term heroin addicts were treated with either methadone hydrochloride or methadyl acetate (dl-methadyl acetate… 
Highly Cited
1971
Highly Cited
1971
Methadone and l-methadyl acetate. Use in management of narcotics addicts.
  • J. JaffeE. Senay
  • Journal of the American Medical Association (JAMA…
  • 1971
  • Corpus ID: 26463919
Ten volunteer patients participating in a methadone hydrochloride maintenance program were assigned randomly to experimental… 
Highly Cited
1970
Highly Cited
1970
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study.
In a double-blind controlled study, d1-α-acetylmethadol hydrochloride a synthetic congener of methadone hydrochloride with a 72… 
Highly Cited
1965
Highly Cited
1965
The metabolism of alpha-dl-acetylmethadol in the rat: the identification of the probable active metabolite.
The major route by which α- dl -acetylmethadol and α- dl -noracetylmethadol are metabolized is by enzymatic N-demethylation. The… 
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