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Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related… Expand Chronic pain not caused by cancer is among the most prevalent and debilitating medical conditions but also among the most… Expand BACKGROUND
The use of prescription opioid medications has increased greatly in the United States during the past two decades; in… Expand IMPORTANCE
Opioid analgesic overdose mortality continues to rise in the United States, driven by increases in prescribing for… Expand Here we provide the updated version of the guidelines of the European Association for Palliative Care (EAPC) on the use of… Expand Since 1990, numerous jurisdictions in the United States (US) have reported increases in drug poisoning mortality. During the same… Expand The problem of abuse of and addiction to opioid analgesics has emerged as a major issue for the United States in the past decade… Expand The description of multiple classes of opioid receptors has had a major impact on our understanding of the mechanisms of… Expand Tramadol hydrochloride produced dose-related antinociception in mouse abdominal constriction [ED50 = 1.9 (1.2-2.6) mg/kg i.p… Expand &NA; Thirty‐eight patients maintained on opioid analgesics for non‐malignant pain were retrospectively evaluated to determine the… Expand