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Central nervous system excitatory effects of meperidine in cancer patients
TLDR
In 48 patients, excitatory effects ranging from mild nervousness to tremors, twitches, multifocal myoclonus, and seizures were directly correlated with accumulation of normeperidine in plasma, suggesting that renal dysfunction may contribute to but is not the sole factor in the accumulation ofnormeperidine or its relation to adverse neurological signs.
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain
TLDR
The results suggest that only the free (unbound) fraction of methadone present in blood is extracted by the liver and that methdone can be classified as a low (hepatic)‐extraction drug.
Clinical evaluation of mild analgesics: the measurement of clinical pain.
TLDR
Conurrent VAS and categorical pain data are able to provide some insight into differences in interpretation of pain by a variety of patient groups, and VAS measurements seem to be more sensitive to smaller changes in effect than are the categorical measurements.
Narcotics in the elderly.
Disposition of acetylmethadol in relation to pharmacologic action
TLDR
The study indicates that the relatively long duration of opiate effects of acetylmethadol results from biotransformation to active and persistent metabolites.
β-Endorphin: Analgesic and hormonal effects in humans
TLDR
Hormonal and analgesic effects of β-endorphin appear to result from the activation of opiate receptors that differ in their locations and characteristics, similar to those of morphine.
Urinary excretion of meperidine by the fetal lamb.
TLDR
A pharmacokinetic model is supported that describes the disposition of meperidine in the maternal-fetal unit by use of a two-compartment open model with elimination from both maternal and fetal compartments and shows that the drug can diffuse across the placental membranes from the mother into these fluids.
Analgesia Produced by a Spinal Action of Morphine and Effects upon Parturition in the Rat
TLDR
It is demonstrated that intrathecal administration has no detectable effect on the initiation of gestation and the viability of the newborn or its respiratory rate, and the significant analgesia and the lack of effect upon respiratory rate and motor function of intr Athecal morphine are supported.
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