Methadone

Known as: Methadonum, (+/-)-Methadone, Methadone [Chemical/Ingredient] 
A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
020040060019462016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
BACKGROUND Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Metabolism and clearance of racemic methadone are stereoselective and highly variable, yet the mechanism remains… (More)
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Highly Cited
2007
Highly Cited
2007
The identification of protein function based on biological information is an area of intense research. Here we consider a… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone… (More)
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Highly Cited
2005
Highly Cited
2005
This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained… (More)
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Highly Cited
2004
Highly Cited
2004
Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome P450 (CYP) isoforms to a stable… (More)
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Highly Cited
2001
Highly Cited
2001
Opioid substitution treatment for dependence may alter sensitivity to pain. Previous studies on pain sensitivity in methadone… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Opioid dependence is a chronic, relapsing disorder with important public health implications. METHODS In a 17-week… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Buprenorphine, a partial mu-agonist and kappa-antagonist, has been proposed as an alternative to methadone for… (More)
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