Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Methadone

Known as: Methadonum, (+/-)-Methadone, Methadone [Chemical/Ingredient] 
A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
IMPORTANCE Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic… Expand
Highly Cited
2010
Highly Cited
2010
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… Expand
  • figure 1
  • table 1
  • table 1
  • table 2
  • figure 2
Review
2007
Review
2007
OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of buprenorphine maintenance therapy (BMT) and methadone… Expand
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Review
2004
Review
2004
BACKGROUND Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of… Expand
Review
2004
Review
2004
The pharmacokinetics of methadone varies greatly from person to person; so, after the administration of the same dose… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • table 7
Review
2003
Review
2003
BACKGROUND Methadone maintenance treatment (MMT) is a long term opioid replacement therapy, recognised as effective in the… Expand
Review
2002
Review
2002
BACKGROUND Methadone maintenance was the first widely used form of opioid replacement therapy developed to treat heroin… Expand
Review
2002
Review
2002
Methadone is widely used for the treatment of opioid dependence. Although in most countries the drug is administered as a racemic… Expand
  • figure 1
  • table I
  • table II
  • figure 2
  • figure 3
Review
2002
Review
2002
Context Several drugs, including antiarrhythmic agents, antihistamines, and tricyclic antidepressants, can cause acquired long-QT… Expand
Highly Cited
2001
Highly Cited
2001
&NA; Opioid substitution treatment for dependence may alter sensitivity to pain. Previous studies on pain sensitivity in… Expand
  • figure 1
  • figure 2
  • figure 3