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Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic… Expand BACKGROUND
Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… Expand OBJECTIVES
To assess the clinical effectiveness and cost-effectiveness of buprenorphine maintenance therapy (BMT) and methadone… Expand BACKGROUND
Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of… Expand The pharmacokinetics of methadone varies greatly from person to person; so, after the administration of the same dose… Expand BACKGROUND
Methadone maintenance treatment (MMT) is a long term opioid replacement therapy, recognised as effective in the… Expand BACKGROUND
Methadone maintenance was the first widely used form of opioid replacement therapy developed to treat heroin… Expand Methadone is widely used for the treatment of opioid dependence. Although in most countries the drug is administered as a racemic… Expand Context Several drugs, including antiarrhythmic agents, antihistamines, and tricyclic antidepressants, can cause acquired long-QT… Expand &NA; Opioid substitution treatment for dependence may alter sensitivity to pain. Previous studies on pain sensitivity in… Expand