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CYP2B6 protein, human

Known as: CPB6, Cytochrome P450 Family 2 Subfamily B Polypeptide 6, cytochrome P450, family 2, subfamily B, polypeptide 6, human 
Cytochrome P450 2B6 (491 aa, ~56 kDa) is encoded by the human CYP2B6 gene. This protein plays a role in the metabolism of steroids and… 
National Institutes of Health

Related topics

Related topics

25 relations
Arachidonic Acid Metabolism PathwayBupropionBupropion HydrochlorideBupropion hydrobromide

Broader (1)

Cytochrome p450 CYP2B6 enzyme

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.
Polymorphisms in drug-metabolizing enzymes and drug transporters contribute to wide and inheritable variability in drug… 
Highly Cited
2003
Highly Cited
2003
Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
Although the glucocorticoid receptor (GR) facilitates the xenobiotic-induced expression of CYP2B in rodents, its role in the… 
Highly Cited
1997
Highly Cited
1997
Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes.
CYP2B, CYP4A, and CYP2E1 mRNA levels are elevated in response to pathophysiological conditions, such as diabetes, high-fat diet… 
Highly Cited
1990
Highly Cited
1990
Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response.
The induction of hepatic cytochromes P-450 by phenobarbital (PB) was studied in rat hepatocytes cultured for up to 5 weeks on… 
Highly Cited
1990
Highly Cited
1990
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
Highly Cited
1989
Highly Cited
1989
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression…
A cDNA designated hIIB1, representing the entire coding sequence of a P450 in the IIB gene family, was isolated from a human… 
Highly Cited
1989
Highly Cited
1989
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.
A novel P450 cDNA was isolated from a rat lung lambda gt11 library by hybridization with the rat P450 IIB1 cDNA probe. The cDNA… 
Highly Cited
1989
Highly Cited
1989
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino…
Highly Cited
1989
Highly Cited
1989
Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase.
Pituitary-determined hormones regulate the expression of hepatic cytochromes P-450 through processes involving both negative and… 
Highly Cited
1974
Highly Cited
1974
Dissection of chromosome structure with trypsin and nucleases.
Exhaustive digestion of chromatin with trypsin leads to the cleavage of only 20-30 amino acids from each of histones III (f3), IV… 
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