FAQ

Bupropion

Known as: Amfebutamone, (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone, BUP 
An aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not… (More)

Topic mentions per year

Topic mentions per year

1977-2017
010020019772017

Related topics

Related topics

34 relations
AnorexiaAttention deficit hyperactivity disorderBulimiaCYP2B6 protein, human
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Broader (4)

Antidepressive AgentsAntidepressive Agents, Second-GenerationCytochrome P-450 CYP2D6 InhibitorsDopamine Uptake Inhibitors

Narrower (11)

AplenzinBW 306UBW 323U66Budeprion
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Bupropion
Depressive disorder
Seizures
Drug Allergy
agonists
Antidepressive Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
BACKGROUND Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available… (More)
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Highly Cited
2006
Highly Cited
2006
Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial.
CONTEXT Varenicline, a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, has the potential to aid smoking… (More)
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Highly Cited
2006
Highly Cited
2006
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.
CONTEXT The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and… (More)
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Highly Cited
2006
Highly Cited
2006
Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.
BACKGROUND After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known… (More)
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Highly Cited
2006
Highly Cited
2006
Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up.
BACKGROUND Currently available smoking cessation therapies have limited success rates. Varenicline tartrate is a novel, selective… (More)
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Highly Cited
2000
Highly Cited
2000
Bupropion is a nicotinic antagonist.
Neuronal nicotinic receptors are ligand-gated ion channels of the central and peripheral central nervous system that regulate… (More)
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Highly Cited
2000
Highly Cited
2000
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing… (More)
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Highly Cited
2000
Highly Cited
2000
Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.
The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP… (More)
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Highly Cited
1999
Highly Cited
1999
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation.
BACKGROUND AND METHODS Use of nicotine-replacement therapies and the antidepressant bupropion helps people stop smoking. We… (More)
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Highly Cited
1997
Highly Cited
1997
A comparison of sustained-release bupropion and placebo for smoking cessation.
BACKGROUND AND METHODS Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double… (More)
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