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Bupropion
Known as:
Amfebutamone
, (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
, BUP
Â
(More)
An aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not…Â
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Topic mentions per year
Topic mentions per year
1977-2017
0
100
200
1977
2017
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Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
Bupropion
Depressive disorder
Seizures
Drug Allergy
agonists
Antidepressive Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Frank L Greenway
,
Ken N Fujioka
,
+5 authors
Eduardo Dunayevich
Lancet
2010
BACKGROUND Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available…Â
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Highly Cited
2006
Highly Cited
2006
Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial.
Douglas E. Jorenby
,
J Taylor Hays
,
+6 authors
Karen R. Reeves
JAMA
2006
CONTEXT Varenicline, a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, has the potential to aid smoking…Â
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Highly Cited
2006
Highly Cited
2006
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.
David Gonzales
,
Stephen I. Rennard
,
+7 authors
Karen R. Reeves
JAMA
2006
CONTEXT The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and…Â
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Highly Cited
2006
Highly Cited
2006
Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.
Augustus John Rush
,
Madhukar H. Trivedi
,
+10 authors
Maurizio Fava
The New England journal of medicine
2006
BACKGROUND After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known…Â
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Highly Cited
2006
Highly Cited
2006
Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up.
Mitchell A Nides
,
Cheryl A. Oncken
,
+4 authors
Karen R. Reeves
Archives of internal medicine
2006
BACKGROUND Currently available smoking cessation therapies have limited success rates. Varenicline tartrate is a novel, selective…Â
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Highly Cited
2000
Highly Cited
2000
Bupropion is a nicotinic antagonist.
Jennifer Elizabeth Slemmer
,
B. R. Martin
,
Mohamad Imad Damaj
The Journal of pharmacology and experimental…
2000
Neuronal nicotinic receptors are ligand-gated ion channels of the central and peripheral central nervous system that regulate…Â
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Highly Cited
2000
Highly Cited
2000
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
Lutz Hesse
,
Karthik Venkatakrishnan
,
+4 authors
David J Greenblatt
Drug metabolism and disposition: the biological…
2000
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing…Â
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Highly Cited
2000
Highly Cited
2000
Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.
Stephanie R. Faucette
,
Ray Hawke
,
+4 authors
Craig Lindley
Drug metabolism and disposition: the biological…
2000
The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP…Â
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Highly Cited
1999
Highly Cited
1999
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation.
Douglas E. Jorenby
,
Scott James Leischow
,
+9 authors
Timothy B. Baker
The New England journal of medicine
1999
BACKGROUND AND METHODS Use of nicotine-replacement therapies and the antidepressant bupropion helps people stop smoking. We…Â
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Highly Cited
1997
Highly Cited
1997
A comparison of sustained-release bupropion and placebo for smoking cessation.
Richard D. Hurt
,
David Sachs
,
+9 authors
P. M. Sullivan
The New England journal of medicine
1997
BACKGROUND AND METHODS Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double…Â
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