Bupropion

Known as: Amfebutamone, (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone, BUP 
An aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not… (More)

Topic mentions per year

Topic mentions per year

1977-2017
010020019772017

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT Varenicline, a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, has the potential to aid smoking… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Currently available smoking cessation therapies have limited success rates. Varenicline tartrate is a novel, selective… (More)
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Highly Cited
2000
Highly Cited
2000
Neuronal nicotinic receptors are ligand-gated ion channels of the central and peripheral central nervous system that regulate… (More)
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Highly Cited
2000
Highly Cited
2000
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing… (More)
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Highly Cited
2000
Highly Cited
2000
The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Use of nicotine-replacement therapies and the antidepressant bupropion helps people stop smoking. We… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND AND METHODS Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double… (More)
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