An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
- M. Guzman, R. M. Rossi, C. Jordan
- Biology, ChemistryBlood
- 15 December 2007
It is proposed that the novel compound DMAPT has the potential to target human LSCs in vivo, which has approximately 70% oral bioavailability and pharmacologic studies using both mouse xenograft models and spontaneous acute canine leukemias demonstrate in vivo bioactivity.
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
- L. Teng, P. Crooks, P. Sonsalla, L. Dwoskin
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 March 1997
The results suggest that, unlike nicotine, lobeline increases DA release by potent inhibition of DA uptake into synaptic vesicles, and a subsequent alteration in presynaptic DA storage.
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.
- L. Dwoskin, P. Crooks
- Biology, PsychologyBiochemical Pharmacology
- 15 January 2002
The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
- D. Worthen, O. Ghosheh, P. Crooks
- Biology, MedicineAnticancer Research
- 1 May 1998
TQ and DIM, which are cytotoxic for several types of human tumor cells, may be MDR substrates, and that radical generation may not be critical to their cytotoxicity activity.
High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).
- O. Ghosheh, A. Houdi, P. Crooks
- Chemistry, MedicineJournal of Pharmaceutical and Biomedical Analysis
- 1 April 1999
Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells*
- Shanshan Pei, M. Minhajuddin, C. Jordan
- Biology, MedicineJournal of Biological Chemistry
- 2 October 2013
It is demonstrated that primitive leukemia cells are uniquely sensitive to agents that target aberrant glutathione metabolism, an intrinsic property of primary human AML cells.
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
- O. Ghosheh, L. Dwoskin, W. K. Li, P. Crooks
- Biology, ChemistryDrug Metabolism And Disposition
- 1 December 1999
It is likely that nornicotine will accumulate in brain on chronic nicotine administration based on the brain half-life of this metabolite, which is also a major alkaloidal component of tobacco.
Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
- H. Gali-Muhtasib, Wassim Abou kheir, Lynn A Kheir, N. Darwiche, P. Crooks
- Biology, MedicineAnti-Cancer Drugs
- 1 April 2004
It is shown that non-cytotoxic concentrations of TQ reduce the proliferation of neoplastic keratinocytes by 50% and support a potential role for TQ as a chemopreventive agent, particularly at the early stages of skin tumorigenesis.
Lobeline Displaces [3H]Dihydrotetrabenazine Binding and Releases [3H]Dopamine from Rat Striatal Synaptic Vesicles: Comparison with d‐Amphetamine
- L. Teng, P. Crooks, L. Dwoskin
- Biology, ChemistryJournal of Neurochemistry
- 1 July 1998
In contrast to d‐amphetamine, which is equipotent in inhibiting DA uptake and promoting release from the synaptic vesicles, lobeline more potently inhibits DA uptake (via an interaction with the DTBZ site on VMAT2) than it evokes DA release to redistribute presynaptic DA storage.
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism
- Dennis K. Miller, L. Wilkins, M. Bardo, P. Crooks, L. Dwoskin
- Biology, PsychologyPsychopharmacology
- 1 August 2001
Nicotinic receptor activation following once-weekly nicotine administration produces long-lasting behavioral sensitization, suggesting that even infrequent nicotine exposure initiates neuroadaptive processes associated with nicotine addiction.
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