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Cytochrome p450 CYP2B6 enzyme

Known as: 1,4 Cineole 2 exo Monooxygenase, Cytochrome P 450 CYP2B6, P450 2B6, Cytochrome 
A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is… 
National Institutes of Health

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CYP2B6 geneCytochrome p450 CYP2A6 enzymeIn BloodProcess of secretion

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CYP2B6 protein, human

Papers overview

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Review
2008
Review
2008
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.
Human CYP2B6 has been thought to account for a minor portion (<1%) of total hepatic cytochrome P450 (CYP) content and to have a… 
Review
2007
Review
2007
Nuclear Receptors and the Regulation of Drug‐Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
Erratic or unpredictable response to drugs remains a challenge of modern drug therapy. An important determinant of such… 
Highly Cited
2007
Highly Cited
2007
Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV‐infected Individuals
To assess the association of CYP2B6 allelic diversity with efavirenz (EFV) pharmacokinetics, we performed extensive genotyping of… 
Highly Cited
2007
Highly Cited
2007
Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6… 
Highly Cited
2004
Highly Cited
2004
Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
The thienopyridine derivatives ticlopidine and clopidogrel are inhibitors of ADP-induced platelet aggregation. Pharmacological… 
Highly Cited
2003
Highly Cited
2003
Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression
CYP2B6 metabolizes many drugs, and its expression varies greatly. CYP2B6 genotype-phenotype associations were determined using… 
Highly Cited
2003
Highly Cited
2003
A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression*
CYP2B6 plays an important role in the metabolism of a variety of structurally unrelated xenobiotics, including the anticancer… 
Highly Cited
2001
Highly Cited
2001
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
The human cytochrome P450, CYP2B6, is involved in the metabolism of several therapeutically important drugs and environmental or… 
Highly Cited
2001
Highly Cited
2001
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
Cytochromes P450 (P450s) are involved in the oxidative metabolism of a plethora of structurally unrelated compounds, including… 
Highly Cited
1999
Highly Cited
1999
Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450.
The effects of methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied in vitro on nine individual… 
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