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Cytochrome p450 CYP2B6 enzyme

Known as: 1,4 Cineole 2 exo Monooxygenase, Cytochrome P 450 CYP2B6, P450 2B6, Cytochrome 
A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is… (More)

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Topic mentions per year

1995-2017
010203019952017

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CYP2B6 geneCytochrome p450 CYP2A6 enzymeIn BloodProcess of secretion
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CYP2B6 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cytochrome p450 CYP2B6 enzyme
physiological aspects
CYP2B6 protein, human
chemical synthesis
Cytochrome p450 CYP2A6 enzyme
standards characteristics

Papers overview

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Highly Cited
2008
Highly Cited
2008
Role of CYP2B6 in stereoselective human methadone metabolism.
BACKGROUND Metabolism and clearance of racemic methadone are stereoselective and highly variable, yet the mechanism remains… (More)
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2007
2007
Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.
Organophosphorus pesticides (OPs) remain a potential concern to human health because of their continuing worldwide use… (More)
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2005
2005
Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.
The oxidative and conjugative metabolism of sertraline was examined in vitro to identify the enzymes involved in the generation… (More)
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Highly Cited
2004
Highly Cited
2004
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.
The objectives of this study were to evaluate the ability of 14 compounds, which differentially activate human pregnane X… (More)
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Highly Cited
2003
Highly Cited
2003
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Cultured human hepatocytes are a valuable in vitro system for evaluating new molecular entities as inducers of cytochrome P450… (More)
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2003
2003
Functional characterization of cytochrome P450 2B6 allelic variants.
Cytochrome P450 (P450) 2B6 is a hepatic enzyme of potential importance for the metabolism of clinically used drugs and… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of cytochromes P450 by antifungal imidazole derivatives.
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug… (More)
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Highly Cited
2000
Highly Cited
2000
Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.
The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in vitro marker of cytochrome P450 (CYP… (More)
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Highly Cited
2000
Highly Cited
2000
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing… (More)
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Highly Cited
1999
Highly Cited
1999
Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin.
AIMS The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes involved in the metabolism of artemisinin… (More)
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