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Cytochrome p450 CYP2B6 enzyme

Known as: 1,4 Cineole 2 exo Monooxygenase, Cytochrome P 450 CYP2B6, P450 2B6, Cytochrome 
A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is… 
National Institutes of Health

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CYP2B6 geneCytochrome p450 CYP2A6 enzymeIn BloodProcess of secretion

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CYP2B6 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients.
2011
2011
Ritonavir inhibits the two main prasugrel bioactivation pathways in vitro: a potential drug-drug interaction in HIV patients.
2008
2008
The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity.
2008
2008
Efavirenz Plasma Concentrations and Cytochrome 2B6 Polymorphisms
Background: Interpatient variability in efavirenz concentrations may be due to CYP2B6 genetic polymorphisms. Efavirenz… 
2008
2008
High-Affinity Binding of [3H]Cimetidine to a Heme-Containing Protein in Rat Brain
[3H]Cimetidine (3HCIM) specifically binds to an unidentified site in the rat brain. Because recently described ligands for this… 
2007
2007
Gene–gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
Objectives CYP2A6 is the major enzyme involved in nicotine metabolism, yet large interindividual variations in the rate of… 
Highly Cited
2005
Highly Cited
2005
CYP2A6 AND CYP2B6 ARE INVOLVED IN NORNICOTINE FORMATION FROM NICOTINE IN HUMANS: INTERINDIVIDUAL DIFFERENCES IN THESE CONTRIBUTIONS
Nornicotine is an N-demethylated metabolite of nicotine. In the present study, human cytochrome P450 (P450) isoform(s) involved… 
2003
2003
Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin
Animals treated with multiple doses of bupropion have had increased bupropion clearance or increased liver weight, suggesting… 
Highly Cited
2002
Highly Cited
2002
Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at… 
Highly Cited
2001
Highly Cited
2001
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.
In view of conflicting data in the literature regarding the enzyme(s) responsible for metabolism of selegiline, a drug used in… 
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