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Psychiatric and substance use comorbidity among treatment-seeking opioid abusers.
BACKGROUND Major studies of psychiatric comorbidity in opioid abusers reported rates of comorbidity that far exceeded general population estimates. These studies were published more than a decade agoExpand
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Clinical pharmacology of buprenorphine: Ceiling effects at high doses
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
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An automated version of the digit symbol substitution test (DSST)
An automated version of the Digit Symbol Substitution Test is described that employs a relatively inexpensive, commercially available microcomputer to present and score the task. Expand
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Acute administration of buprenorphine in humans: partial agonist and blockade effects.
Buprenorphine, a mixed opioid agonist-antagonist, is being investigated as a treatment for opioid dependence. This study compared the acute subjective and physiological effects of sublingualExpand
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Principles of initial experimental drug abuse liability assessment in humans.
This paper describes the rationale and procedures for conducting what is considered by many to be the current "gold standard" for initial abuse liability testing of a novel compound: the classicExpand
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A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oralExpand
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Characteristics of older opioid maintenance patients.
The aging "baby boomer" population has higher rates of substance use than previous cohorts and is predicted to put increased demands on substance abuse treatment services; however, little is knownExpand
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Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial.
CONTEXT Methadone hydrochloride treatment is the most common pharmacological intervention for opioid dependence, and recent interest has focused on expanding methadone treatment availability beyondExpand
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A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
BACKGROUND Opioid dependence is a chronic, relapsing disorder with important public health implications. METHODS In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75Expand
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Acute physical dependence in man: effects of naloxone after brief morphine exposure.
This study assessed the effects of i.m. naloxone (10 mg) 6 hr after acute i.m. injections of morphine (0, 1, 3, 5.6, 10 and 17 mg). Naloxone reversed residual morphine-produced respiratoryExpand
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