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- Publications
- Influence
Psychiatric and substance use comorbidity among treatment-seeking opioid abusers.
- R. Brooner, V. King, M. Kidorf, C. Schmidt, G. Bigelow
- Psychology, Medicine
- Archives of general psychiatry
- 1997
BACKGROUND
Major studies of psychiatric comorbidity in opioid abusers reported rates of comorbidity that far exceeded general population estimates. These studies were published more than a decade ago… Expand
Clinical pharmacology of buprenorphine: Ceiling effects at high doses
- S. Walsh, K. Preston, M. Stitzer, E. Cone, G. Bigelow
- Medicine
- Clinical pharmacology and therapeutics
- 1 May 1994
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
An automated version of the digit symbol substitution test (DSST)
- D. Mcleod, R. Griffiths, G. Bigelow, J. Yingling
- Medicine, Computer Science
- 1 September 1982
TLDR
Acute administration of buprenorphine in humans: partial agonist and blockade effects.
- S. Walsh, K. Preston, G. Bigelow, M. Stitzer
- Medicine
- The Journal of pharmacology and experimental…
- 1 July 1995
Buprenorphine, a mixed opioid agonist-antagonist, is being investigated as a treatment for opioid dependence. This study compared the acute subjective and physiological effects of sublingual… Expand
Principles of initial experimental drug abuse liability assessment in humans.
- R. Griffiths, G. Bigelow, N. Ator
- Psychology, Medicine
- Drug and alcohol dependence
- 5 June 2003
This paper describes the rationale and procedures for conducting what is considered by many to be the current "gold standard" for initial abuse liability testing of a novel compound: the classic… Expand
A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
- W. Bickel, M. Stitzer, G. Bigelow, I. Liebson, D. Jasinski, R. Johnson
- Medicine
- Clinical pharmacology and therapeutics
- 1 January 1988
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oral… Expand
Characteristics of older opioid maintenance patients.
- M. Lofwall, R. Brooner, G. Bigelow, Kori Kindbom, E. Strain
- Medicine
- Journal of substance abuse treatment
- 1 April 2005
The aging "baby boomer" population has higher rates of substance use than previous cohorts and is predicted to put increased demands on substance abuse treatment services; however, little is known… Expand
Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial.
- E. Strain, G. Bigelow, I. Liebson, M. Stitzer
- Medicine
- JAMA
- 17 March 1999
CONTEXT
Methadone hydrochloride treatment is the most common pharmacological intervention for opioid dependence, and recent interest has focused on expanding methadone treatment availability beyond… Expand
A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
- R. Johnson, M. A. Chutuape, E. Strain, S. Walsh, M. Stitzer, G. Bigelow
- Medicine
- The New England journal of medicine
- 2 November 2000
BACKGROUND
Opioid dependence is a chronic, relapsing disorder with important public health implications.
METHODS
In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75… Expand
Acute physical dependence in man: effects of naloxone after brief morphine exposure.
- W. Bickel, M. Stitzer, I. Liebson, G. Bigelow
- Medicine
- The Journal of pharmacology and experimental…
- 1988
This study assessed the effects of i.m. naloxone (10 mg) 6 hr after acute i.m. injections of morphine (0, 1, 3, 5.6, 10 and 17 mg). Naloxone reversed residual morphine-produced respiratory… Expand