G. Bigelow

Publications416
h-index75
Citations19,787
Highly Influential Citations569
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Psychiatric and substance use comorbidity among treatment-seeking opioid abusers.
TLDR
The positive associations between psychiatric comorbidity and severity of substance use and other psychosocial problems were most consistent among those with antisocial personality.
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Clinical pharmacology of buprenorphine: Ceiling effects at high doses
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
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College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement.
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An automated version of the digit symbol substitution test (DSST)
TLDR
An automated version of the Digit Symbol Substitution Test is described that employs a relatively inexpensive, commercially available microcomputer to present and score the task, and task performance data for individual subjects following doses of pentobarbital are presented.
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Acute administration of buprenorphine in humans: partial agonist and blockade effects.
TLDR
There is a ceiling on the effects of buprenorphine in humans that may reduce its abuse liability and increase its safety, and indicate that opioid blockade occurs after acute administration of bu p.o.m. or methadone.
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A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
TLDR
The results of this clinical trial indicated that buprenorphine was acceptable to patients and as effective as methadone in the detoxification treatment of heroin addicts.
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Characteristics of older opioid maintenance patients.
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Principles of initial experimental drug abuse liability assessment in humans.
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A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
TLDR
As compared with low-dose methadone, levomethadyl acetate, buprenorphine, and high-dose Methadone substantially reduce the use of illicit opioids.
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Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial.
TLDR
Both moderate- and high-dose Methadone treatment resulted in decreased illicit opioid use during methadone maintenance and detoxification, and the high- dose group had significantly greater decreases in illicit opioids use.
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