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A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oralExpand
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Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial.
CONTEXT Methadone hydrochloride treatment is the most common pharmacological intervention for opioid dependence, and recent interest has focused on expanding methadone treatment availability beyondExpand
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Acute physical dependence in man: effects of naloxone after brief morphine exposure.
This study assessed the effects of i.m. naloxone (10 mg) 6 hr after acute i.m. injections of morphine (0, 1, 3, 5.6, 10 and 17 mg). Naloxone reversed residual morphine-produced respiratoryExpand
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Comparison of buprenorphine and methadone in the treatment of opioid dependence.
OBJECTIVE This study compared the efficacy of buprenorphine and methadone in the treatment of opioid dependence. METHOD Participants (N = 164) were relatively treatment-naive, opioid-dependentExpand
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Buprenorphine: dose-related blockade of opioid challenge effects in opioid dependent humans.
This study assessed the blockade of hydromorphone challenge effects (cumulative s.c. doses of 0, 6 and 18 mg) during chronic buprenorphine treatment of opioid dependent subjects. Buprenorphine wasExpand
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Dose-Response Effects of Methadone in the Treatment of Opioid Dependence
It is estimated that more than 500 000 people in the United States are dependent on opioids [1, 2]. Methadone, a synthetic opioid first reported as a treatment agent for opioid dependence by Dole andExpand
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Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure.
Antagonist-precipitated withdrawal after acute opioid administration (acute physical dependence) is an interesting phenomenon in that the opioid abstinence syndrome is generally thought to developExpand
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Acute opioid physical dependence in humans: Effect of naloxone at 6 and 24 hours postmorphine
Previous studies in our laboratory have documented the occurrence of naloxone-precipitated opioid abstinence from 45 minutes to 6 hours after acute morphine administration in humans. This studyExpand
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Buprenorphine alone and in combination with naloxone in non-dependent humans.
This study evaluated the effects of concurrent naloxone on the opioid agonist effects of buprenorphine, a mixed agonist-antagonist marketed as an analgesic and under development as a treatment forExpand
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Buprenorphine and naloxone alone and in combination in opioid-dependent humans
Subjective, physiological and behavioral effects of subcutaneously administered hydromorphone (6 mg), naloxone (0.2 mg), buprenorphine (0.2 and 0.3 mg), and two buprenorphine-naloxone combinationsExpand
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