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Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humans.
The cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") were assessed in a double-blind, randomized, crossover, and controlled…
Non-linear pharmacokinetics of MDMA ('ecstasy') in humans.
- R. de la Torre, M. Farré, J. Camí
- Biology, MedicineBritish journal of clinical pharmacology
- 1 February 2000
The lack of linearity of MDMA pharmacokinetics (in a window of doses compatible with its recreational use) is a more general phenomenon as it concerns the whole population independent of their CYP2D6 genotype.
Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition.
The impact of CYP2D6 pharmacogenetics on acute toxicity is limited and one of the interesting features of MDMA metabolism is its potential involvement in the development of mid- to long-term neurotoxic effects as a result of progressive neurodegeneration of the serotonergic neurotransmission system.
Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effects.
The short-term administration of MDMA produced marked euphoria, a slight impairment in the performance of psychomotor tasks, and mild changes in body perceptions without hallucinations, which support the abuse liability of MDMA.
Pharmacology of MDMA in Humans
- R. Torre, M. Farré, J. Camí
- Medicine, BiologyAnnals of the New York Academy of Sciences
- 1 September 2000
Drug concentrations increased, and a parallel increase in physiologic and hormonal measures was observed, and MDMA induced a slight dose‐dependent impairment on psychomotor performance.
3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics.
- C. Hernández-López, M. Farré, R. de la Torre
- MedicineThe Journal of pharmacology and experimental…
MDMA reversed the subjective sedation induced by alcohol but did not reduce drunkenness feelings, and the MDMA-alcohol combination induced longer lasting euphoria and well being than MDMA or alcohol alone.
Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics
Pharmacological effects after the second administration of MDMA were higher than those following the first but lower than expected, and a disproportionate increase in plasma concentrations in MDMA and MDA was observed most likely due to metabolic inhibition.
Alcohol and cocaine interactions in humans.
- M. Farré, R. de la Torre, J. Camí
- Medicine, PsychologyThe Journal of pharmacology and experimental…
- 1 September 1993
The combination of COC and alcohol induced a nonsignificant decrease in the subjective feelings of drunkeness, an increase in COC-induced euphoria, a significant improvement in alcohol-related changes in psychomotor performance and a marked increase in heart rate.
Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis.
Stereoselective disposition of MDMA and MDA was confirmed and HMMA disposition seems to be in apparent contradiction with MDMA findings as the enantiomer ratio is close to 1 and constant over the time.
Pharmacokinetic considerations in abuse liability evaluation.
Variations in drug metabolism may be related to dose-dependent kinetics, first-pass metabolism, and variations in genetic traits (e.g. poor or extensive metabolizers).