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Metabotropic Glutamate Receptor 2, human

Known as: Glutamate Metabotropic Receptor 2, Metabotropic Glutamate Receptor 2, Glutamate Receptor Homolog 
Metabotropic glutamate receptor 2 (872 aa, ~96 kDa) is encoded by the human GRM2 gene. This protein plays a role in neurotransmitter-dependent… 
National Institutes of Health

Related topics

Related topics

14 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM2 geneIntegral Membrane Proteins

Broader (1)

metabotropic glutamate receptor 2

Papers overview

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2019
2019
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.
G protein-coupled receptors (GPCRs) are membrane proteins that play important roles in biology. However, our understanding of… 
Highly Cited
2014
Highly Cited
2014
Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity
Objective Epigenetic mechanisms are potential targets to relieve somatic pain. However, little is known whether epigenetic… 
Highly Cited
2013
Highly Cited
2013
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption
Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part… 
Highly Cited
2010
Highly Cited
2010
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
2010
2010
Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.
Using an mGluR2 FRET-based binding assay, binders of the transmembrane region devoid of functional activity were identified. It… 
Highly Cited
2007
Highly Cited
2007
Heterogeneity of glycinergic and gabaergic interneurons in the granule cell layer of mouse cerebellum
Interneurons of the cerebellum granule cell layer (GCL) form distinct populations. Golgi cells extend dendrites in the molecular… 
Highly Cited
2005
Highly Cited
2005
Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice
Rationale(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) is a potent and selective agonist for group… 
2005
2005
Reduced expression of metabotropic glutamate receptor 2mRNA in T cells of ALS patients
Metabotropic glutamate receptors alter the vulnerability of neurons to excitotoxic damage and are reported to display abnormal… 
Highly Cited
2004
Highly Cited
2004
Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
Herein we disclose the discovery of a new class of positive allosteric potentiators of the metabotropic glutamate receptor 2… 
Highly Cited
2000
Highly Cited
2000
Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice.
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