Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
- J. Gomeza, H. Shannon, J. Wess
- BiologyProceedings of the National Academy of Sciences…
- 16 February 1999
The M2 muscarinic receptor subtype, besides its well documented involvement in the regulation of heart rate, plays a key role in mediating muscaric receptor-dependent movement and temperature control as well as antinociceptive responses, three of the most prominent central muscarinate effects.
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.
The observed improvements in ADAS-Cog and CIBIC+ following treatment with xanomeline provide the first evidence, from a large-scale, placebo-controlled clinical trial, that a direct-acting muscarinic receptor agonist can improve cognitive function in patients with AD.
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice
- S. Gleason, H. Shannon
- Psychology, BiologyPsychopharmacology
- 1997
The present findings support the hypothesis that antagonism at 5-HT2A receptors contributes to the in vivo actions of atypical antipsychotics such as olanzapine and clozapine, and indicate that PCP increases locomotor activity, at least in part, due to actions at5- HT2A, but not 5- HT3 or5-HT1A, receptors.
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
- Thomas J. Raub, G. Wishart, Alfonso de Dios
- Biology, MedicineDrug Metabolism And Disposition
- 1 September 2015
Data show that abemaciclib crosses the blood–brain barrier and confirm that both CDK4 and CDK6 inhibitors reach unbound brain levels in rodents that are expected to produce enzyme inhibition; however, abemACiclib brain levels are reached more efficiently at presumably lower doses than palbociclib and are potentially on target for a longer period of time.
Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats
- C. Jones, E. L. Eberle, David B. Shaw, D. McKinzie, H. Shannon
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 March 2005
It is demonstrated that a functional interaction occurs between the mus carinic cholinergic and dopaminergic systems in modulating PPI and that muscarinic Cholinergic receptor agonists may be effective in the treatment of the P PI and other cognitive impairments observed in schizophrenia.
Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.
- H. Shannon, F. Bymaster, P. Sauerberg
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 April 1994
The present data are consistent with the interpretation that xanomeline is a novel muscarinic receptor agonist with functional selectivity for M1 mus carinic receptors both in vitro and in vivo.
Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice
- A. Linden, H. Shannon, M. Baez, J. Yu, A. Koester, D. Schoepp
- Biology, PsychologyPsychopharmacology
- 1 April 2005
The activation of bothmGlu2 and mGlu3 receptors by LY354740 appears to be required for anxiolytic-like activity in the EPM test in mice, and these studies serve as a foundation for additional studies on underlying circuits, brain structures, and receptor subtypes involved in the anxiety-related actions of mGLU receptor active agents, and the design of future drugs for anxiety disorders in humans.
Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.
- C. Jones, H. Shannon
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 September 2000
The present findings demonstrate that the muscarinic cholinergic system plays an important role in the normal mechanisms of PPI, and is reversed in a dose-dependent manner by the mus carinic receptor agonist oxotremorine.
Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models
- M. Barton, S. Peters, H. Shannon
- BiologyEpilepsy Research
- 1 September 2003
m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT2C receptors but not 5-HT2A or 5-HT2B receptors
- S. Gleason, V. Lucaites, H. Shannon, D. Nelson, J. Leander
- Biology, PsychologyBehavioural Pharmacology
- 1 December 2001
A detailed pharmacological evaluation with selective antagonists for the 5-HT2 family of receptors supports a primary role for the 1-(m-chlorophenyl)piperazine receptor in mediating the hypolocomotion produced by m-CPP.
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