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- Publications
- Influence
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
- J. Gomeza, H. Shannon, +6 authors J. Wess
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 February 1999
Members of the muscarinic acetylcholine receptor family (M1-M5) are known to be involved in a great number of important central and peripheral physiological and pathophysiological processes. Because… Expand
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.
OBJECTIVE
To evaluate the therapeutic effects of selective cholinergic replacement with xanomeline tartrate, an m1 and m4 selective muscarinic receptor (mAChR) agonist in patients with probable… Expand
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice
- S. Gleason, H. Shannon
- Chemistry, Medicine
- Psychopharmacology
- 1997
Abstract In humans, phencyclidine (PCP) is known to produce a syndrome of behavioral effects which have many characteristics in common with schizophrenia. Therefore, antagonism of PCP effects might… Expand
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
- Thomas J. Raub, G. Wishart, +7 authors Alfonso De Dios
- Medicine
- Drug Metabolism and Disposition
- 1 September 2015
Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase… Expand
Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.
- H. Shannon, F. Bymaster, +10 authors P. Sauerberg
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 April 1994
Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1- methylpyridine] has been evaluated as a muscarinic receptor agonist. In vitro, xanomeline had high affinity for muscarinic… Expand
Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats
- C. Jones, E. L. Eberle, David B Shaw, D. Mckinzie, H. Shannon
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 March 2005
Prepulse inhibition (PPI) of the acoustic startle reflex is a sensorimotor gating process known to be deficient in a number of neurologic and psychiatric conditions, including schizophrenia. Multiple… Expand
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
- J. Gomeza, L. Zhang, +7 authors J. Wess
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 31 August 1999
Muscarinic acetylcholine receptors (M(1)-M(5)) regulate many key functions of the central and peripheral nervous system. Primarily because of the lack of receptor subtype-selective ligands, the… Expand
Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.
- C. Jones, H. Shannon
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 September 2000
The purpose of the present study was to determine the effects of muscarinic cholinergic receptor antagonists and agonists on prepulse inhibition (PPI) of the acoustic startle reflex in rats. The… Expand
Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure models
- M. E. Barton, S. Peters, H. Shannon
- Chemistry, Medicine
- Epilepsy Research
- 1 September 2003
Glutamatergic ionotropic and metabotropic receptor modulators have been shown to produce anticonvulsant activity in a number of animal seizure models, e.g. maximal electroshock (MES) and DBA/2… Expand
The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.
The therapeutic effects of selective cholinergic replacement using oral xanomeline, an m1/m4 receptor agonist, were assessed in a multicenter study of 343 patients with Alzheimer disease (AD).… Expand